摘要
目的 观察痛风康联合针刺疗法治疗湿热蕴结型痛风性关节炎(GA)的临床疗效。方法 选取2021年4月~2022年4月宿州市中医医院骨科收治的60例湿热蕴结型GA患者作为研究对象,采用随机数字表法分为中药组和西药组,每组各30例。中药组给予痛风康联合针刺疗法,西药组常规口服秋水仙碱治疗,疗程均为14d。观察两组患者关节疼痛评分、关节肿胀评分、炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)]、空腹血尿酸(UA)水平、总有效率及不良反应发生率。结果 与治疗前比较,治疗后两组患者关节疼痛评分、关节肿胀评分及空腹血UA水平、TNF-α水平、IL-1β水平均降低,差异均有统计学意义(P<0.05),而两组间上述指标比较差异无统计学意义(P>0.05)。中药组总有效率93.33%,西药组总有效率90.00%,两组比较差异无统计学意义(P>0.05);中药组的不良反应发生率6.67%,明显低于西药组(33.33%),两组比较差异有统计学意义(P<0.05)。结论 痛风康联合针刺疗法与秋水仙碱治疗湿热蕴结型GA在抗炎、消肿、止痛方面疗效显著,均具有降低空腹血UA作用,但痛风康联合针刺疗法治疗湿热蕴结型GA不良反应发生率较低。
Objective To observe the clinical efficacy of Tongfengkang combined with acupuncture therapy in the treatment of damp heat accumulation type gouty arthritis(GA).Methods A total of 60 patients with damp-heat accumulation type of gout admitted to the Department of Orthopedics of Suzhou Hospital of Traditional Chinese Medicine from April 2021 to April 2022 were selected as the research subjects and randomly divided into a traditional Chinese medicine group and a western medicine group,with 30 cases in each group.The traditional Chinese medicine group was treated with Tongfengkang combined with acupuncture therapy,while the western medicine group was treated with conventional oral colchicine therapy.Both groups were treated for 14 days.The joint pain score,joint swelling score,inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β)],fasting blood uric acid(UA)level,total effective rate,and adverse reaction rate were observed in both groups.Results Compared with before treatment,the joint pain score,joint swelling score,fasting blood UA level,TNF-αlevel,and IL-1βlevel in both groups decreased after treatment,and the differences were statistically significant(P<0.05).However,there was no significant difference in the above indicators between the two groups(P>0.05).The total effective rate of the traditional Chinese medicine group was 93.33%,and the total effective rate of the western medicine group was 90.00%.There was no significant difference between the two groups(P>0.05).The adverse reaction rate in the traditional Chinese medicine group was 6.67%,which was significantly lower than that in the western medicine group(33.33%),and the difference between the two groups was statistically significant(P<0.05).Conclusion The combination of Tongfengkang and acupuncture therapy with colchicine has significant effects on the treatment of damp-heat accumulation type of GA in terms of anti-inflammation,detumescence,and pain relief,and all have the effect of reducing fasting blood UA.However,the incidence
作者
尤元梅
袁松
You Yuanmei;Yuan Song(Department of Clinical Medicine and Medical Technology,North Anhui Health Vocational College,Suzhou 234000,China)
出处
《华北理工大学学报（医学版）》
2023年第6期460-465,共6页
Journal of North China University of Science and Technology：Health Sciences Edition
基金
安徽高校科学研究重点研究项目(编号:KJ2020A1147)。
