摘要
为了对磁感应热疗作用于胰腺导管腺癌时的效果进行研究,根据真实的人体数据构建三维的人体腹部、胰腺、胰腺导管和肿瘤模型,采取亥姆霍兹线圈用作产生交变磁场的热疗装置。在有限元仿真分析软件COMSOL中进行电磁与传热模块的耦合后,得到磁感应热疗作用于胰腺导管腺癌时的磁场和温度场的仿真结果。结果表明,治疗区域的空间磁场分布均匀,温度场分布满足热疗需要。胰腺导管腺癌在进行磁感应热疗时,肿瘤组织的温度可以迅速升高,达到42℃以上,而周围正常组织升温不显著。此外,研究还证实了胰腺导管周围存在的大血管、磁流体溢出等因素对热疗的疗效没有太大的影响,仿真结果能够为胰腺导管腺癌的磁感应热疗临床实践提供参考。
The effect of magnetic induction hyperthermia on pancreatic ductal adenocarcinoma(PDAC)is analyzed using a three-dimensional model of human abdomen,pancreas,pancreatic duct and tumor constructed based on real human data,and a Helmholtz coil is used as a hyperthermia device to generate alternating magnetic fields.The simulation results of magnetic field and temperature field of magnetic induction hyperthermia acting on PDAC are obtained after coupling electromagnetic and heat transfer modules in the finite element calculation and analysis software COMSOL.The results reveal that the spatial distribution of the magnetic field in the treatment area is relatively uniform,and that the temperature field distribution can provide the optimal temperature for hyperthermia.When magnetic induction hyperthermia is performed for PDAC,the temperature of the tumor tissue can rise rapidly to over 42℃,while the surrounding normal tissue does not heat up remarkably.In addition,the study also confirmes that the factors such as the existence of large blood vessels near the pancreatic ducts and magnetic fluid overflow have trivial effects on the efficacy of hyperthermia treatment.The simulation results can be a reference for the clinical implementation of magnetic induction hyperthermia for PDAC.
作者
张恒
逯迈
ZHANG Heng;LU Mai(Key Laboratory of Optoelectronic Technology and Intelligent Control of Ministry of Education,Lanzhou Jiaotong University,Lanzhou 730070,China)
出处
《中国医学物理学杂志》
CSCD
2023年第11期1408-1417,共10页
Chinese Journal of Medical Physics
基金
国家自然科学基金(51567015,51867014)。
关键词
胰腺导管腺癌
磁感应热疗
有限元分析
磁介质
pancreatic ductal adenocarcinoma
magnetic fluid hyperthermia
finite element analysis
magnetic medium
