摘要
目的:探讨耳穴揿针联合清燥布津汤治疗干燥综合征(SS)阴虚津亏证患者的疗效及安全性,为SS的治疗提供新思路。方法:纳入SS阴虚津亏证患者66例,分为试验组(耳穴揿针联合清燥布津汤)和对照组(清燥布津汤),每组33例。疗程为12周。观察两组患者治疗前后中医证候积分及中医证候疗效,欧洲抗风湿病联盟制定的干燥综合征疾病活动指数、患者自我报告指数(ESSDAI、ESSPRI),Schirmer试验、唾液流率试验,血沉(ESR)、免疫球蛋白G(IgG)、焦虑自评量表(SAS)、抑郁自评量表(SDS)、疲劳量表(FSS)、匹兹堡睡眠质量指数量表(PSQI)评分变化情况。结果:中医证候总有效率试验组(87.10%,27/31)显著高于对照组(73.33%,22/30)(P<0.05)。除ESSDAI评分、ESR、对照组患者PSQI评分外,两组患者其余各项指标治疗后较治疗前均不同程度改善(P<0.05)。治疗后试验组中医证候积分,ESSPRI,SAS、FSS及PSQI评分显著低于对照组(P<0.05)。结论:耳穴揿针与清燥布津汤联用相比单用清燥布津汤,总有效率明显提升,并在降低中医证候积分、ESSPRI评分及改善抑郁、疲劳状态、睡眠方面的作用更为明显,值得临床推广。
Objective:To explore the efficacy and safety of ear point pressing needle combined with Qingzao Bujin Decoction in the treatment of patients with Sjogren's syndrome(SS)with yin deficiency and fluid deficiency,to provide new ideas for treatment.Methods:A total of 66 patients with SS in yin deficiency and fluid deficiency syndrome were divided into an experimental group(auricular point thumbtack needling combined with Qingzao Bujin Decoction)and a control group(Qingzao Bujin Decoction)with 33 cases in each group.The treatment period was 12 weeks.Observing the TCM syndrome score and TCM syndrome efficacy of two groups of patients before and after treatment,EULAR Sjogren's Syndrome Disease Activity Index(ESSDAI),and EULAR Sjogren's Syndrome Patient Reported Index(ESSPRI),Schirmer test,saliva flow rate test,changes in erythrocyte sedimentation rate(ESR),immunoglobulin G(IgG),Self-Rating Anxiety Scale(SAS),Self-Rating Depression Scale(SDS),Fatigue Severity Scale(FSS)and Pittsburgh Sleep Quality Index(PSQI)scores.Results:The total effective rate of traditional Chinese medicine syndrome in the experimental group(87.10%,27/31)was significantly higher than that in the control group(73.33%,22/30)(P<0.05).Except for the ESSDAI score,ESR,and PSQI score of control group patients,all other indicators of the two groups of patients improved to varying degrees after treatment compared to before treatment(P<0.05).After treatment,the TCM syndrome scores,ESSPRI,SAS,FSS,and PSQI scores of the experimental group were significantly lower than those of the control group(P<0.05).Conclusion:Compared with the combination of ear acupoint pressing needle and Qingzao Bujin Decoction,using Qingzao Bujin Decoction alone significantly improves the overall effective rate,and has a more significant effect on reducing traditional Chinese medicine syndrome scores,ESSPRI scores,and improving depression,fatigue,and sleep.It is worthyofclinical promotion.
作者
王梦洁
罗雅文
刘英
姜萍
WANG Mengjie;LUO Yawen;LIU Ying;JIANG Ping(Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250000,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2023年第11期5596-5600,共5页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家中医药管理局第三届国医大师传承工作室及全国名中医传承工作室建设项目(No.国中医药办人教函[2018]119号)
山东省卫生健康委员会2020年齐鲁医派中医学术流派传承项目(No.鲁卫函[2020]132号)。
关键词
干燥综合征
耳穴揿针
清燥布津汤
阴虚津亏证
Sjogren's syndrome(SS)
Auricular point thumbtack needling
Qingzao Bujin Decoction
Yin deficiency and fluid deficiency syndrome
