摘要
目的探究中药复方专利治疗糖尿病视网膜病变(DR)的用药规律。方法检索中国知识资源总库(CNKI)专利数据库建库至2022年9月1日公开发表的治疗DR的中药复方专利,采用古今医案云平台V2.0对用药频次与性味、归经分布进行分析,基于关联规则与聚类分析方法对配伍用药规律进行挖掘分析。结果共纳入复方专利113个,包括中药201味,其中使用频次排名前5位依次为生地黄、三七、当归、灵芝、黄芪,用药药性以寒、温居多,药味以甘、苦为主,归经多为肝、肺、肾经。常用药对6对,聚类分析得出4类药物;复杂网络分析得到核心中药组合为生地黄、三七、当归、灵芝、黄芪、丹参、枸杞子、蕤仁、菟丝子。结论治疗DR专利复方药物以甘寒、归肝经为主,用药以益气养阴、清热凉血、活血化瘀、补益肝肾为主,常用益气养阴、清热解毒、补气养血、补气止血药对,组方多以当归补血汤、四物汤等加减,酌加风药平肝明目,可为临床提供参考。
Objective To explore the law of Chinese medicine patent compound prescription in treating diabetic retinopathy(DR).Methods The patents of TCM compound for the treatment of DR Published in the patent database of China National Knowledge Resource Database(CNKI)from the establishment of the database to September 1,2022 were searched and screened.The Ancient and Modern Medical Record Cloud Platform V2.0 was used to analyze the frequency of medication,nature,taste,and meridian distribution,and the rules of compatibility of medication were mined and analyzed based on association rules and cluster analysis.Results A total of 113 compound patents were included,involving 201 kinds of Chinese materia medica.The top five drugs in frequency of use were Rehmanniae Radix,Notoginseng Radix et Rhizoma,Angelicae Sinensis Radix,Ganoderma and Astragali Radix.Their properties were mostly cold and warm,and their tastes were sweet and bitter.The top three meridians were liver meridian,lung meridian and kidney meridian.Six pairs of commonly used drugs were obtained,and four kinds of medicines were obtained by clustering analysis.Complex network analysis showed that core TCM combination was Rehmanniae Radix,Notoginseng Radix et Rhizoma,Angelicae Sinensis Radix,Ganoderma,Astragali Radix,Salviae Miltiorrhizae Radix et Rhizoma,Lycii Fructus,Prinsepiae Nux,and Cuscutae Semen.Conclusions TCM compound patents for the treatment of DR are mainly used to treat cold and liver meridian,and the medication is mainly used to replenish qi and nourish yin,clear heat and cool blood,promote blood circulation and remove blood stasis,and tonify liver and kidney.The drug pairs are mainly used to supplement qi and nourish yin,clear heat and detoxify,invigorate qi and nourish blood,and invigorate qi and stop bleeding.The modified Danggui Buxue Decoction and Siwu Decoction are often used in treatment,and wind drugs are added as appropriate to soothe liver and improve eyesight,which can provide reference for clinic.
作者
毛舒心
喻嵘
Mao Shuxin;Yu Rong(Hunan University of Chinese Medicine,Changsha 410208,China;The First School of Clinical Medicine,Hunan University of Chinese Medicine,Changsha 410007,China;Graduate School,Hunan University of Chinese Medicine,Changsha 410208,China)
出处
《国际中医中药杂志》
2023年第11期1448-1452,共5页
International Journal of Traditional Chinese Medicine
基金
国家自然科学基金项目(82074400,U21A20411)
湖南省重点研发计划项目(2020SK2101)。
