摘要
高温易引起绵羊热应激,热应激时下丘脑-垂体-肾上腺轴(The hypothalamic-pituitary-adrenal axis,HPA)和交感-肾上腺髓质轴(The sympathetico-adrenomedullary axis,SAM)兴奋,引起体内多种激素水平变化,以抵抗热应激对机体的影响;同时产生大量的活性氧(ROS)和活性氮(RNS)通过核因子E2相关因子2(Nuclear factor erythroid 2-related factor 2,Nrf2)、抗氧化反应元件(Antioxidant response element,ARE)、核转录因子kB(Nuclear factor kappa-B,NF-κB)等信号通路,调控抗氧化酶及细胞因子的表达与分泌。高温引发的热应激最终会导致绵羊生长和繁殖能力降低。本文主要阐述了热应激时绵羊体内激素水平的变化,以及氧化应激信号通路、天然免疫和适应性免疫的调控作用,以期为减轻热应激对绵羊机体氧化损伤及免疫功能影响的研究提供参考依据。
High temperature can cause heat stress in sheep.During heat stress,the hypothalamus-pituitary-adrenal axis(HPA)and the sympathetic-adrenomedullary axis(SAM)are excited,causing changes in various hormone levels in the body to resist the effects of heat stress.At the same time,a large amount of reactive oxygen species(ROS)and reactive nitrogen species(RNS)are produced,which regulate the expression and secretion of antioxidant enzymes and cytokines through nuclear factor erythroid 2-related factor 2(Nrf2),antioxidant response element(ARE),nuclear factor kappa-B(NF-κB)and other signaling pathways.The heat stress induced by high temperature can eventually lead to reduced growth and reproductive capacity of sheep.This article mainly described the changes of hormone levels in sheep during heat stress,as well as the regulatory effects of oxidative stress signaling pathways,natural immunity,and adaptive immunity,in order to provide reference for the study of reducing the effects of heat stress on oxidative damage and immune function in sheep.
作者
李述方
王海荣
LI Shu-fang;WANG Hai-rong(Inner Mongolia Key Laboratory of Animal Nutrition and Feed Science/College of Animal Science,Inner Mongolia Agricultural University,Hohhot 010018,China)
出处
《江苏农业学报》
CSCD
北大核心
2023年第7期1606-1612,共7页
Jiangsu Journal of Agricultural Sciences
基金
国家自然科学基金项目(31860658)
内蒙古农业大学标志性成果专项基金项目(BZCG202011)。
关键词
热应激
绵羊
内分泌激素
氧化应激信号通路
免疫
heat stress
sheep
endocrine hormones
oxidative stress signaling pathway
immunity
