摘要
目的探讨血塞通冻干粉联合硫辛酸治疗糖尿病伴脑梗死的临床效果。方法选取2019年7月至2021年7月收治的110例糖尿病伴脑梗死患者为研究对象,根据入院单双号将其分为对照组(55例,丹参注射液+硫辛酸)和研究组(55例,血塞通冻干粉+硫辛酸)。比较两组的治疗效果。结果研究组的治疗总有效率高于对照组(P<0.05)。治疗后,研究组的空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)、胰岛素抵抗指数(HOMA-IR)、可溶性细胞间黏附分子-1(sICAM-1)、白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、美国国立卫生院卒中量表(NIHSS)评分、全血黏度、红细胞压积、红细胞最大聚集指数及纤维蛋白原水平低于对照组,胰岛素分泌指数(HOMA-β)高于对照组(P<0.05)。结论相较于丹参注射液,血塞通冻干粉联合硫辛酸治疗糖尿病伴脑梗死的效果更优,其可改善胰岛功能,调节血糖水平及血液流变学指标,促进神经功能恢复。
Objective To explore the clinical effect of Xuesaitong lyophilized powder combined with thioctic acid in the treatment of diabetes mellitus with cerebral infarction.Methods A total of 110 patients with diabetes mellitus with cerebral infarction admitted from July 2019 to July 2021 were selected as the research objects.According to the odd and even numbers of admission,the patients were divided into control group(55 cases,Danshen injection+thioctic acid)and study group(55 cases,Xuesaitong lyophilized powder+thioctic acid).The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the study group was higher than that in the control group(P<0.05).After treatment,the fasting blood glucose(FBG),2 hour postprandial plasam glucose(2 h PG),glycated hemoglobin(HbA1c),homeostasis model assessment of insulin resistance(HOMA-IR),soluble intercellular adhesion molecule-1(sICAM-1),interleukin-6(IL-6),high-sensitive C-reactive protein(hs-CRP),National Institutes of Health Stroke Scale(NIHSS)score,whole blood viscosity,hematocrit,erythrocyte maximum aggregation index and fibrinogen level in the study group were lower than those in the control group,and the homeostatic model assessment-β(HOMA-β)was higher than that in the control group(P<0.05).Conclusion Compared with Danshen injection,Xuesaitong lyophilized powder combined with thioctic acid is more effective in the treatment of diabetes mellitus with cerebral infarction,it can improve islet function,regulate blood glucose level and hemorheological indexes,and promote the recovery of neurological function.
作者
杨春梅
余橦
李云云
赵莉
苏衍进
YANG Chunmei;YU Tong;LI Yunyun;ZHAO Li;SU Yanjin(No.2 Ward of Encephalopathy Department,Xi'an Hospital of Traditional Chinese Medicine,Xi'an 710021;Shaanxi University of Chinese Medicine,Xianyang 712046;No.1 Endocrinology Department,Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000;the First Clinical Medical College of Shaanxi University of Chinese Medicine,Xianyang 712000,China)
出处
《临床医学研究与实践》
2023年第33期71-74,共4页
Clinical Research and Practice
基金
陕西中医药大学附属医院2020年度陕西省科技计划项目(No.2020SF-336)。
关键词
血塞通冻干粉
丹参注射液
硫辛酸
糖尿病
脑梗死
Xuesaitong lyophilized powder
Danshen injection
thioctic acid
diabetes mellitus
cerebral infarction
