摘要
近年来,工业化污染严重导致各类细菌滋生,致病性细菌感染可通过各种方式进行快速传播,存在很大的感染风险。因此,开发高性能的抑菌材料并研究其抑菌机制具有重要的应用价值。为了解决这一问题,本文设计通过亚氯酸钠溶液改性锆基金属-有机骨架材料UiO-66-NH_(2),制备了一种新型纳米复合抑菌材料UiO-66-NHCl,采用XRD、FTIR、SEM、TEM、EDS和XPS等对金属-有机骨架(MOF)复合材料结构和化学组成进行表征,同时探索不同负载工艺对氯负载量的影响,并对UiO-66-NHCl复合材料的抑菌性能及皮肤刺激性实验进行研究。结果表明:通过浸渍键合的方法在UiO-66-NH_(2)上引入了活性氯,改变UiO-66-NH_(2)在NaClO_(2)溶液中的氯负载比例(质量比m(UiO-66-NH_(2))∶m(NaClO_(2)))和氯化时间可以提高氯负载量,当氯负载比例为1∶5、氯化时间为4 h时,氯负载量最高;在高温、高湿和强光等条件下,仍能保持其原始氯负载量的80%,有较好的稳定性。抑菌活性表明,相比于原始UiO-66-NH_(2)材料,UiO-66-NHCl复合材料对金黄色葡萄球菌和大肠杆菌均有抑制作用,氯含量较高的样品显示出较高的抑菌效果,且无刺激性。
In recent years,serious industrial pollution has led to the growth of various types of bacteria,and pathogenic bacterial infections can be spread rapidly by various means,posing a great risk of infection.Therefore,it is important to develop high-performance antibacterial materials and study their antibacterial mechanisms for application.To address this issue,this work designed a novel nanocomposite bacteriostatic material UiO-66-NHCl by modifying zirconium-based metal-organic backbone material UiO-66-NH_(2)via sodium chlorite solution,and characterized the structure and chemical composition of metal-organic framework(MOF)composites by using XRD,FTIR,SEM,TEM,EDS and XPS,and the effects of different loading processes on the chlorine loading were also explored,and the antibacterial properties and skin irritation experiments of UiO-66-NHCl composites were investigated.The results show that the active chlorine is introduced on UiO-66-NH_(2)by impregnation bonding,and the chlorine loading can be increased by changing the chlorine loading ratio(mass ratios m(UiO-66-NH_(2))∶m(NaClO_(2)))and chlorination time of UiO-66-NH_(2)in NaClO_(2)solution,and the highest chlorine loading is achieved when the chlorine loading ratio is 1∶5 and the chlorination time is 4 h.Under the conditions of high temperature,high humidity and high temperature,it can still maintain 80%of its original chlorine loading and has good stability.The inhibition activity show that the UiO-66-NHCl composites inhibit both Staphylococcus aureus and Escherichia coli compared to the original UiO-66-NH_(2)material,and the samples with higher chlorine content show higher inhibition effect and no irritation.
作者
谷娜
王田田
李红
任伟杰
董倩茹
高金龙
GU Na;WANG Tiantian;LI Hong;REN Weijie;DONG Qianru;GAO Jinlong(School of Chemical and Pharmaceutical Engineering,Hebei University of Science and Technology,Shijiazhuang 050018,China;School of Science,Hebei University of Science and Technology,Shijiazhuang 050018,China)
出处
《复合材料学报》
EI
CAS
CSCD
北大核心
2023年第10期5760-5771,共12页
Acta Materiae Compositae Sinica
关键词
金属-有机骨架
亚氯酸钠
改性
稳定性
抑菌
metal-organic framework
sodium hypochlorite
modified
stability
antibacterial
