摘要
目的分析2018—2021年泰西地区慢性丙型肝炎流行趋势及肝脏功能损害情况,为该地区丙肝患者预防肝脏功能损害提供参考依据。方法从中国疾病预防控制中心传染病报告信息管理系统下载泰西地区报告的丙肝病例数据,采用描述流行病学方法分析丙肝流行病学特点,从医院HIS系统中收集,包括患者性别、年龄、居住地、吸烟史、饮酒史、治疗药物、基因分型等临床资料,根据患者是否肝功能损伤分为肝功能损伤组和对照组,采用单因素分析和logistic回归分析泰西地区丙肝患者肝脏功能损害的因素。结果2018—2021年报告550例丙肝病例,无死亡病例;男性292例,女性258例;平均年龄53.47±5.74岁,不同年龄段男女构成间差异无统计学意义(χ^(2)=1.472,P>0.05);40~59岁所占比例明显高于20~39岁和≥60岁患者;职业构成以农民为主(占44.36%),居住地主要为农村(占52.18%)。发生肝功能损伤129例(23.45%),肝功能损伤组ALT、AST、GGT值明显高于对照组(P<0.05),ALB值明显低于对照组(P<0.05);两组在平均年龄、饮酒史、合并糖尿病、基因分型、HCV-RNA病毒载量、CD4^(+)CD25^(+)Treg间差异具有统计学意义(P<0.05);CD4^(+)CD25^(+)Treg<5%、1b型基因分型、HCV-RNA高载量是泰西地区丙肝患者肝脏功能损害的的独立危险因素(P<0.05)。结论2018—2021年泰西地区丙肝发病率较高,对于CD4^(+)CD25^(+)Treg>5%、1b型基因分型、HCV-RNA高载量的丙肝患者发生肝功能受损的风险较高,应积极进行治疗,降低肝功能损伤的发生。
Objective To analyze the prevalence trend of chronic hepatitis C and liver function impairment in Taixi area from 2018 to 2021,and to provide theoretical basis for preventing liver function impairment in hepatitis C patients in Taixi area.Methods The data of hepatitis C cases reported in Taixi were downloaded from the infectious disease reporting Information management system of Chinese Center for Disease Control and Prevention,and the epidemiological characteristics of hepatitis C were analyzed by descriptive epidemiological methods.The clinical data including gender,age,place of residence,smoking history,drinking history,therapeutic drugs,genotyping and other clinical data were collected from HIS system of the hospital.Patients were divided into liver function injury group and control group according to whether they had liver function injury.Univariate analysis and logistic regression were used to analyze the factors of liver function injury in hepatitis C patients in Taixi area.Results Among the 550 cases reported from 2018 to 2021,there were no deaths,including 292 males and 258 females.The male cases were more than the female cases,and the average age was(53.47±5.74)years old.There was no significant difference in the composition of male and female cases among different age groups(χ^(2)=1.472,P>0.05).From 2018 to 2021,the proportion of patients aged 40 to 59 was significantly higher than that of patients aged 20 to 39 and≥60.The occupation composition was mainly farmers,accounting for 44.36%(244/550),and 287 cases(52.18%)lived mainly in rural areas.From 2018 to 2021,129(23.45%)of 550 patients with hepatitis C had liver function injury.ALT,AST and GGT values in the liver function injury group were significantly higher than those in the control group(P<0.05).The ALB value of liver function injury group was significantly lower than that of control group(P<0.05).There were statistically significant differences between the two groups in mean age,drinking history,diabetes mellitus,genotyping,HCV-RNA viral load
作者
罗真真
纪元
田海英
LUO Zhenzhen;JI Yuan;TIAN Haiying(Department of Laboratory,The Second Affiliated Hospital of Shandong First Medical University,Tai'an,Shandong 271000,China;School of Public Health and Health Management,Shandong First Medical University,Tai'an,Shandong 271000,China)
出处
《公共卫生与预防医学》
2023年第6期112-115,共4页
Journal of Public Health and Preventive Medicine
关键词
慢性丙型肝炎
肝脏功能损害
流行趋势
Chronic hepatitis C
Liver function impairment
Epidemic Trends
