摘要
目的:分析益生菌联合美沙拉秦治疗非特异性小肠溃疡的临床效果。方法:选取2018年5月—2023年5月苏州永鼎医院消化科收治的非特异性小肠溃疡患者72例作为研究对象,按照随机数字表法分为两组,各36例。对照组应用美沙拉秦治疗,试验组在对照组基础上应用益生菌治疗。比较两组临床疗效、炎性因子水平、症状积分、不良反应发生率及生活质量。结果:试验组总有效率高于对照组,差异有统计学意义(P=0.024);治疗后,试验组生理功能、社会功能、精神状态、心理健康、生命活力评分均高于对照组,差异有统计学意义(P<0.01);治疗后,试验组腹痛、腹胀、腹泻积分均低于对照组,差异有统计学意义(P<0.001);试验组不良反应总发生率低于对照组,差异有统计学意义(P=0.041)。结论:益生菌联合美沙拉秦治疗非特异性小肠溃疡效果显著,不仅能减轻患者的临床症状,改善炎性因子水平,还能降低不良反应发生率,提高患者生活质量。
Objective:To analyze the therapeutic effect of probiotics combined with mesalazine in the treatment of non-specific small intestine ulcer.Methods:72 patients with non-specific small intestinal ulcers admitted to the Department of Gastroenterolo⁃gy of Suzhou Yongding Hospital from May 2018 to May 2023 were selected as the study subjects,and they were divided into two groups of 36 cases each according to the method of randomized numerical table.The control group was treated with mesalazine,and the experimental group with probiotics on the basis of the control group.The two groups were compared in terms of therapeutic effect,inflammatory factor level,clinical symptom,incidence of adverse reactions and quality of life.Results:The total effective rate of the experimental group was higher than that of the control group,and the difference was statistically significant(P=0.024);the scaled scores of physiological function,social function,mental state,mental health and life vitality of the experimental group after treatment were higher than those of the control group,and the difference was statistically significant(P<0.01);the scores of abdominal pain,abdominal distension and diarrhea of the experimental group after treatment were lower than those of the control group,and the difference was statistically significant(P<0.001);the total incidence of adverse reactions in the test group was low⁃er than that in the control group,and the difference was statistically significant(P=0.041).Conclusion:Probiotics combined with mesalazine is effective in treating non-specific small bowel ulcer,which can not only reduce the clinical symptoms of patients and improve the level of inflammatory factors,but also reduce the incidence of adverse reactions and improve the quality of life of patients.
作者
沈志刚
Shen Zhigang(Department of Gastroenterology,Suzhou Yongding Hospital,Suzhou 215200,Jiangsu Province,China)
出处
《中外医药研究》
2023年第18期3-5,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
关键词
非特异性小肠溃疡
益生菌
美沙拉秦
炎性反应
Non-specific small intestinal ulcer
Probiotics
Mesalazine
Inflammatory response
