摘要
空间代谢组学是基于质谱成像和代谢组学技术发展而来的一门新兴组学技术,通过原位检测生物体系中内源性小分子和外源性药物代谢物的分子结构、空间分布及含量变化,精准地反映代谢物在组织整体或微区的代谢网络变化特征,深度揭示中药的药效物质基础及作用机制。通过对近年来空间代谢组学技术在中药质量控制、中药在生物体内代谢及分布、中药药效机制和中药毒性机制中的研究成果进行综述,为探索基于空间代谢组学技术的中药研究提供理论依据。
Spatial metabolomics is an emerging technology based on the development of mass spectrometry imaging and metabolomics technology,which accurately reflects the metabolic network changes of metabolites in the whole or micro regions of the tissue by detecting the molecular structure,spatial distribution,and content changes of endogenous small molecules and exogenous drug metabolites in biological systems in-situ,and reveals the efficacy material basis and mechanism of traditional Chinese medicine(TCM)in depth.This study aims to review the research achievements of spatial metabolomics technology in the quality control,metabolism and distribution in organism,pharmacodynamic mechanism,and the toxicity mechanism of TCM in recent years,providing a theoretical basis for exploring the research of TCM based on spatial metabolomics technology.
作者
赵杰
冯素香
ZHAO Jie;FENG Su-xiang(Academy of Chinese Medical Sciences,Henan University of Chinese Medicine,Zhengzhou 450000,China;Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-constructed by Henan province&Education Ministry of P.R.,Henan University of Chinese Medicine,Zhengzhou 450000,China)
出处
《中草药》
CAS
CSCD
北大核心
2023年第20期6569-6579,共11页
Chinese Traditional and Herbal Drugs
基金
河南省中医药科学研究专项课题(2023ZY1029)
河南省科技攻关项目(232102311215)
中国博士后科学基金(2020M672244)。
关键词
空间代谢组学
中药
质量控制
体内代谢及分布
药效机制
毒性机制
spatial metabolomics
traditional Chinese medicine
quality control
metabolism and distribution in vivo
pharmacodynamic mechanism
toxicity mechanism
