摘要
骨质疏松症是一种常见的代谢性骨疾病,其发病机制与骨内稳态的失衡密切相关。骨内稳态依赖于破骨细胞的骨吸收和成骨细胞的骨形成之间的精确动态平衡,并涉及一系列复杂且高度调节的步骤。越来越多的证据表明,自噬是免疫细胞、骨细胞分化与活化的必需过程,自噬失调可导致骨免疫紊乱,直接或间接引起OB/OC比例失调,导致骨稳态失衡。本综述以“伏毒”理论为切入点,以“伏毒-细胞自噬-骨免疫”学说为基础,探讨自噬、骨免疫学与OP的关系,为OP的治疗及进一步的研究提供一定的理论参考依据。
Osteoporosis is a common metabolic bone disease.Its pathogenesis is closely related to the imbalance of bone homeostasis.Bone homeostasis depends on a precise dynamic balance between bone resorption by osteoclasts and bone formation by osteoblasts,and involves a series of complex and highly regulated steps.More and more evidences show that autophagy is an essential process for the differentiation and activation of immune cells and bone cells.The disorder of autophagy leads to the disorder of bone immunity,directly or indirectly causing the imbalance of OB/OC ratio,Results ing in the imbalance of bone homeostasis.This review takes the theory of"vototoxicity"as the starting point and the theory of"vototoxicity-autophagy-bone immunity"as the basis to explore the relationship among autophagy,bone immunology,and OP,so as to provide certain theoretical reference for the treatment and further research of OP.
作者
李平顺
田杰祥
周孟茹
魏勇
王钢
LI Pingshun;TIAN Jiexiang;ZHOU Mengru;WEI Yong;WANG Gang(The Affiliated Hospital of Gansu University of Traditional Chinese Medicine,Lanzhou 73000,China;Gansu University of Traditional Chinese Medicine,Lanzhou 73000,China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2023年第10期1508-1512,1549,共6页
Chinese Journal of Osteoporosis
基金
国家自然科学基金项目(基于骨免疫探讨补肾通络法对类风湿关节炎骨破坏及Treg/Th17的影响及机制研究,81860858)
国家自然科学基金项目(基于NF-κB信号通路探讨补肾通络法治疗类风湿性关节炎骨破坏的机制研究,81960832)
甘肃省青年科技基金项目(基于“肾主骨”理论探讨补肾通络方对CIA大鼠滑膜组织中骨破坏相关蛋白的影响研究,22JR11RA133)
甘肃中医药大学第二附属医院院内青年项目(基于“伏毒-细胞自噬-骨免疫”学说探讨补肾通络方通过PI3K/AKT/mTOR通路对CIA大鼠FLS增殖、凋亡和自噬的影响,ZX-62000004-2022-092)。
关键词
伏毒
细胞自噬
骨免疫
骨质疏松症
vototoxicity
autophagy
bone immunity
osteoporosis
