摘要
肺癌是最常见的恶性肿瘤之一。在国内,肺癌的死亡率在恶性肿瘤中居于首位,严重危害我国人民的健康。如何及时且快速地改善患者生命质量、延长生命期限,是急需解决的问题。肌肉减少症是指与年龄相关的肌肉质量丧失,伴肌肉力量减低或身体功能低下。肌肉减少症可由慢性疾病、运动不足、营养不良和药物副作用等多种因素导致。同时,肌肉减少症在肺癌、胃癌、肝癌、食管癌等多种类型肿瘤中发病率较高,也是影响肿瘤预后的独立危险因素。目前,虽然肺癌患者合并肌肉减少症的情况很常见,但病理生理学发病机制尚不明确。因此,本文就肌肉减少症的定义与诊断、肺癌相关肌肉减少症的发病机制以及肌肉减少症对肺癌不同治疗方式患者预后的影响等方面进行综述,为预防肺癌相关肌肉减少症提供理论基础。
Lung cancer is one of the most common malignant tumors.In China the mortality rate of lung cancer ranks first among malignant tumors seriously endangering the health of Chinese people.Faced with this current situation how to timely and quickly improve the quality of life of patients and extend their lifespan is an urgent problem to be solved.Sarcopenia refers to age-related muscle mass loss accompanied by decreased muscle strength or physical dysfunction.Sarcopenia can be caused by many factors such as chronic diseases lack of exercise malnutrition and drug side effects.At the same time more and more studies have also proved that sarcopenia has a high incidence rate in lung cancer gastric cancer liver cancer esophageal cancer and other types of tumors and it is also an independent risk factor affecting the prognosis of tumors.At present although sarcopenia is common in lung cancer patients the pathophysiology is still unclear.Therefore this article reviews the definition and diagnosis of sarcopenia the pathogenesis of lung cancer-related sarcopenia and the impact of sarcopenia on the prognosis of lung cancer patients with different treatment methods so as to provide a theoretical basis for the prevention of lung cancer related sarcopenia.
作者
魏芯芯
薛伟
李利廷
Wei Xinxin;Xue Wei;Li Liting(Department of Nephrology and Endocrinology Handan Hospital of Traditional Chinese Medicine,Handan 056000 Hebei China;Department of Nutrition The First Hospital of Hebei Medical University,Shijiazhuang 050031 Hebei China;Department of Radiology The First Hospital of Hebei Medical University Hebei Key Laboratory of Nutrition and Health,Shijiazhuang 050031 Hebei China)
出处
《肿瘤代谢与营养电子杂志》
2023年第5期679-683,共5页
Electronic Journal of Metabolism and Nutrition of Cancer
基金
河北省卫健委医学科学研究课题计划项目(20231059)。
关键词
肌肉减少症
肺癌
预后
Sarcopenia
Lung cancer
Prognosis
