摘要
肺癌是我国发病率和死亡率最高的恶性肿瘤。改善肺癌、肺结节患者的预后关键在于早诊早治。近年来无创/微创液体活检、多组学及人工智能技术的发展很大程度上提高了肺癌、肺结节早诊的准确性,但尚无一种灵敏度和特异度俱佳的早期诊断方法。此外,早期精准手术方式及切除范围、局部精准治疗、围手术期联合治疗及术后复发转移监测仍然是肺癌、肺结节早治亟待解决的问题。综合各种治疗策略的优势,制定个体化精准治疗方案是进一步改善患者长期生存的关键,未来在探索新的治疗策略的同时,需要持续探索标志物筛选治疗有效人群,并开展大样本随机对照临床研究探索多元化治疗策略下的患者长期生存获益情况。
Lung cancer remains the most prevalent and lethal malignancy in our country.Early diagnosis and treatment are crucial for improving patient prognosis in lung cancer/pulmonary nodules.Recent advancements in non-invasive/minimally invasive liquid biopsy,multi-omics,and artificial intelligence technologies have significantly enhanced the accuracy of early lung cancer/pulmonary nodule diagnosis.However,an early diagnostic method with both high sensitivity and specificity is yet to be established.Furthermore,addressing the methods and extent of early precision surgery,local precision therapy,perioperative combined treatment,and postoperative recurrence and metastasis monitoring are urgent challenges in the early management of lung cancer/pulmonary nodules.Integrating the advantages of various treatment strategies and formulating personalized and precise treatment plans is key to further improving patient survival.In the future,while exploring new therapeutic strategies,it is necessary to continuously search for biomarkers to identify the population that will benefit from the treatment effectively.Additionally,large-sample randomized controlled clinical studies should be conducted to investigate the benefits of long-term patient survival under a diverse range of treatment strategies.
作者
吴凤
殷峥嵘
郑浩然
许娟娟
杨光海
金阳
Wu Feng;Yin Zhengrong;Zheng Haoran;Xu Juanjuan;Yang Guanghai;Jin Yang(Department of Respiratory and Critical Care Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Key Laboratory of Respiratory Diseases of National Health Commission,MOE Key Laboratory of Biological Targeted Therapy,Hubei Province Clinical Research Center for Major Respiratory Diseases,Hubei Province Engineering Research Center for Tumor-Targeted Biochemotherapy,Hubei Province Key Laboratory of Biological Targeted Therapy,Wuhan 430022,China;Department of Thoracic Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)
出处
《中华医学杂志》
CAS
CSCD
北大核心
2024年第18期1547-1554,共8页
National Medical Journal of China
基金
国家重点研发计划(2022YFF1203300)
国家自然科学基金(82330003)
湖北省重点研发计划(2022BCA016、2023BCB146)
关键词
肺肿瘤
肺结节
早期诊断
围手术期
精准治疗
Lung neoplasms
Pulmonary nodules
Early diagnosis
Perioperative period
Precision therapy
