摘要
多囊卵巢综合征(PCOS)引起的卵泡发育、排卵障碍以及代谢紊乱等问题严重影响育龄期女性的月经及生殖功能,并可导致一系列病理变化。微RNA(miRNA)作为调控转录后基因表达的非编码RNA,也是目前PCOS领域的研究热点。PCOS患者卵泡液内miRNA表达具有一定特点,其中差异表达的miRNA参与调节卵巢颗粒细胞增殖与凋亡异常、氧化应激及高雄激素分泌等PCOS相关病理变化的基因表达,且其表达水平与胰岛素抵抗、高雄激素血症等PCOS合并症相关。因此,卵泡液内miRNA可能成为PCOS防治的新靶点及其诊断分型、预测治疗结局的生物标志物,具有重要的研究价值。
Polycystic ovary syndrome(PCOS)caused follicular development,ovulation disorders and metabolic disorders seriously affect the menstrual and reproductive function of women of reproductive age,and can lead to a series of pathological changes.MicroRNA(miRNA),as non-coding RNA that regulates post-transcriptional gene expression,is also the research focus in the field of PCOS.The expression of miRNA in follicular fluid of PCOS patients has certain characteristics,in which differentially expressed miRNA is involved in regulating the gene expression of PCOS-related pathological changes such as abnormal proliferation and apoptosis of ovarian granulosa cells,oxidative stress and hyperandrogen secretion,and their expression levels are related to the complications of PCOS such as insulin resistance and hyperandrogenemia.Therefore,miRNA in follicular fluid may become a new target for the prevention and treatment of PCOS,as well as a biomarker for diagnosis and classification,and prediction of treatment outcome,which has important research value.
作者
苗婧
康志媛
郭淼
MIAO Jing;KANG Zhiyuan;GUO Miao(Henan University of Chinese Medicine,Zhengzhou 450046,China;Department of Gynecology and Obstetrics,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)
出处
《医学综述》
CAS
2023年第20期4191-4196,共6页
Medical Recapitulate
基金
河南省中医药科学研究专项课题(20-21ZY2008)。
