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D-二聚体阳性患者发生急性肺栓塞的危险因素及临床预测模型 被引量:1

Risk factors and clinical prediction model of acute pulmonary embolism in D-dimer patients
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摘要 目的探讨D-二聚体阳性患者发生急性肺栓塞(APE)的危险因素及临床预测模型。方法回顾性分析本院2018年5月—2022年10月D-二聚体阳性(>0.25 mg/L)拟诊APE的病例119例,以CTPA作为金标准,分为肺栓塞组(66例)与非肺栓塞组(53例),收集一般资料,合并症,实验室结果,采用先单后多的方法,建立临床预测模型,采用ROC曲线进行诊断性分析。结果2组患者的D-二聚体、PaCO_(2)、LDL-C、DVT差异有统计学意义(P<0.05);LDL-C、PaCO_(2)、DVT形成、D二聚体>0.5 mg/L 4个指标建立临床预测模型(P<0.05);ROC曲线分析,AUC为0.759(95%CI:0.672~0.846),有一定的预测价值。结论D-二聚体(>0.5 mg/L)、高LDL-C、DVT形成、低PaCO_(2)是发生APE的独立危险因素,建立的预测模型有一定的临床预测价值。 Objective This paper aims to investigate the risk factors and clinical prediction model of acute pulmonary embolism(APE)in patients with D-dimer.Methods Retrospective analysis was made on 119 patients with D-dimer(>0.25 mg/L)who were suspected of acute pulmonary embolism in our hospital from May 2018 to October 2022.Pulmonary artery CTA was used as the gold standard for diagnosing pulmonary embolism,and the patients were divided into pulmonary embolism group(66 cases)and non-pulmonary embolism group(53 cases).General information,complications,and laboratory results were collected.A single before multiple method was used to establish a clinical prediction model,and ROC curve was used for diagnostic analysis.Results There was statistical significance on the differences in D-dimer,PaCO_(2),LDL-C and DVT between the two groups(P<0.05).The clinical prediction model of LDL-C,PaCO_(2),DVT formation and D dimer>0.5 mg/L was established(P<0.05).ROC curve analysis showed that AUC(0.759,95%CI:0.672-0.846)had certain predictive value.Conclusion D-dimer(>0.5 mg/L),high LDL-C,DVT formation and low PaCO_(2) are independent risk factors for acute pulmonary embolism.The prediction model established by the four indicators has certain clinical predictive value.
作者 王晶晶 吴滨 WANG Jing-jing;WU Bin(Xiaoshan Hospital,Hangzhou,Hangzhou,Zhejiang 311200,China)
机构地区 浙江萧山医院
出处 《中国卫生检验杂志》 CAS 2023年第19期2393-2397,共5页 Chinese Journal of Health Laboratory Technology
关键词 D-二聚体 肺栓塞 下肢静脉血栓 血气分析 诊断 D-dimer Pulmonary embolism Lower extremity venous thrombosis Blood gas analysis Diagnosis
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