摘要
目的了解高龄经产妇合并生殖道支原体感染对常用抗菌药物的敏感性。方法回顾性分析2016年1月1日至2021年12月31日在解放军联勤保障部队第九〇八医院妇产科住院的320例高龄经产妇宫颈分泌物支原体培养阳性菌株药敏试验结果。结果高龄经产妇宫颈分泌物支原体培养标本320例中,201例支原体培养阳性,其中单纯解脲脲原体感染164例(51.3%),解脲脲原体与人型支原体混合感染31例(9.7%),单纯人型支原体感染6例(1.8%)。单纯解脲脲原体感染时,美满霉素、强力霉素的耐药率分别为6.1%和5.5%,阿奇霉素、交沙霉素、罗红霉素和克拉霉素的耐药率分别为21.9%、20.7%、23.8%和18.9%,氟喹诺酮类司帕沙星、加替沙星的耐药率分别为48.8%和42.1%,氟喹诺酮类和大环内酯类的耐药率高于四环素类,差异具有统计学意义(P<0.05);解脲脲原体混合人型支原体感染时,氟喹诺酮类和大环内酯类耐药率显著高于四环素类,差异具有统计学意义(P<0.05);单纯人型支原体感染时,大环内酯类药物耐药率显著高于四环素和氟喹诺酮类,差异具有统计学意义(P<0.05)。结论高龄经产妇宫颈分泌物支原体感染以单纯解脲脲原体为主,解脲脲原体混合人型支原体为感染其次,单纯人型支原体感染较少。单纯解脲脲原体感染和混合人型支原体感染时,氟喹诺酮类耐药率相对较高,单纯人型支原体感染时大环内酯类的耐药率更高,临床应根据药敏试验结果选择最佳的抗菌药物。
Objective To investigate the sensitivity of the elderly multiparous women with genital tract mycoplasma infection to commonly used antibiotics.Methods Retrospective analysis was made on the results of drug susceptibility test of mycoplasma culture positive strains in cervical secretions of elderly multiparous women hospitalized in Department of Gynecology and Obstetrics of the 908th Hospital of the Joint Logistics Support Force from January 1,2016 to December 31,2021.Results A total of 320 samples of mycoplasma culture from cervical secretion of elderly multiparous women were collected,201 of which were positive for mycoplasma culture,including 164 cases(51.3%)of pure ureaplasma urealyticum infection,31 cases(9.7%)of mixed ureaplasma urealyticum and mycoplasma hominis infection,and 6 cases(1.8%)of pure mycoplasma hominis infection.When ureaplasma urealyticum was isolated,the drug resistance rates of minocycline and doxycycline were 6.1%and 5.5%,respectively.The drug resistance rates of azithromycin,josamycin,roxithromycin and clarithromycin were 21.9%,20.7%,23.8%and 18.9%,respectively.The drug resistance rates of fluoroquinolones sparfloxacin and gatifloxacin were 48.8%and 42.1%,respectively.And the drug resistance rates of fluoroquinolones and macrolides were higher than those of tetracyclines(P<0.05).When ureaplasma urealyticum mixed with mmycoplasma hominis infection,the drug resistance rates of fluoroquinolones and macrolides were significantly higher than that of tetracyclines(P<0.05).The drug resistance rate of macrolides was significantly higher than that of tetracyclines and fluoroquinolones in the case of mycoplasma hominis infection alone(P<0.05).Conclusion Ureaplasma urealyticum is the main pathogen in the cervical secretion of the elderly multiparous women.Ureaplasma urealyticum mixed with mycoplasma hominis is the second,and mycoplasma hominis infection alone is less.The drug resistance rate of fluoroquinolones is relatively high in ureaplasma urealyticum infection alone and mixed mycoplasma hominis
作者
宁丽萍
吴豫
袁美晶
赵婉茹
周媛
叶心周
万艳
刘思
NING Liping;WU Yu;YUAN Meijing;ZHAO Wanru;ZHOU Yuan;YE Xinzhou;WAN Yan;LIU Si(Department of Clinical Laboratory,the 908th Hospital of the Joint Logistics Support Force,PLA,Nanchang 330002,Jiangxi,China)
出处
《医学研究与战创伤救治》
CAS
北大核心
2023年第6期619-622,共4页
Journal of Medical Research & Combat Trauma Care
关键词
高龄
经产妇
支原体
药敏试验
elderly
multiparous women
mycoplasma
drug susceptibility analysis
