摘要
目的探讨急性荨麻疹(AU)患者血清维生素D各组分水平与疾病严重程度、伴随系统症状的相关性。方法选取2020年3月-2021年4月于我院皮肤科就诊的67例AU患者作为疾病组,另外选取同期于我院体检的50例健康人作为健康组,检测两组血清总25(OH)D、25(OH)D2、25(OH)D3及游离25(OH)D水平,比较两组血清25(OH)D各组分水平;按荨麻疹活动度评分将AU患者分为轻度组、中度组和重度组,分析疾病组25(OH)D各组分水平与疾病严重程度、伴随系统症状的相关性。结果疾病组血清总25(OH)D、25(OH)D3及游离25(OH)D低于健康组,差异有统计学意义(P<0.05);两组25(OH)D2比较,差异无统计学意义(P>0.05);疾病组维生素D缺乏者比例高于健康组(34.33%vs.12.00%),差异有统计学意义(P<0.05);重度组血清总25(OH)D、25(OH)D3及游离25(OH)D低于轻、中度组,但仅轻度组与重度组间比较,差异有统计学意义(P<0.05);疾病组病情严重程度与维生素D缺乏程度呈正相关(r=0.353);伴系统症状的AU患者血清总25(OH)D、25(OH)D3及游离25(OH)D均低于无系统症状组,差异有统计学意义(P<0.05),两者25(OH)D2比较,差异无统计学意义(P>0.05)。结论急性荨麻疹患者血清维生素D水平低于健康人,维生素D缺乏越多疾病可能越严重,低维生素D水平状态的AU患者可能更易合并系统症状。
Objective To investigate the correlation of vitamin D components'levels with disease severity and concomitant system symptoms in patients with acute urticaria(AU).Methods A total of 67 patients with AU who were treated in the Department of Dermatology of our hospital from March 2020 to April 2021 were selected as the disease group,and 50 healthy people who underwent physical examination in our hospital during the same period were selected as the healthy group.The levels of serum total 25(OH)D,25(OH)D2,25(OH)D3 and free 25(OH)D in the two groups were detected,and the levels of serum 25(OH)D components in the two groups were compared.According to the urticaria activity score,AU patients were divided into mild group,moderate group and severe group.The correlation between the levels of 25(OH)D components and the severity of the disease and the accompanying systemic symptoms was analyzed.Results The serum total 25(OH)D,25(OH)D3 and free 25(OH)D in the disease group were lower than those in the healthy group,and the difference was statistically significant(P<0.05),while there was no significant difference in 25(OH)D2 between the two groups(P>0.05).The proportion of vitamin D deficiency in the disease group was higher than that in the healthy group(34.33%vs.12.00%),and the difference was statistically significant(P<0.05).The serum total 25(OH)D,25(OH)D3 and free 25(OH)D in the severe group were lower than those in the mild and moderate groups,but only the difference between the mild and severe groups was statistically significant(P<0.05).The severity of the disease group was positively correlated with the degree of vitamin D deficiency(r=0.353).The levels of serum total 25(OH)D,25(OH)D3 and free 25(OH)D in AU patients with systemic symptoms were lower than those in AU patients without systemic symptoms,and the differences were statistically significant(P<0.05).There was no significant difference in 25(OH)D2 between the two groups(P>0.05).Conclusion The serum vitamin D level of patients with acute urticaria is lower than
作者
李燕
何沅莉
罗家昂
易清玲
LI Yan;HE Yuan-li;LUO Jia-ang;YI Qing-ling(Department of Dermatology1,Department of Rheumatology and Immunology,University of Electronic Science and Technology of China,Mianyang 621000,Sichuan,China;Mianyang Central Hospita1,School of Medicine,University of Electronic Science and Technology of China,Mianyang 621000,Sichuan,China)
出处
《医学信息》
2023年第21期122-125,共4页
Journal of Medical Information
基金
绵阳市中心医院院级课题(编号:2020YJ14、2020YJ12)。
