摘要
经颅电刺激作为一种具有广泛应用潜力的神经调控技术,在人体平衡的研究方面仅停留在外在表现上,对人体平衡的神经调节影响机制尚不明确。脑功能网络是理解大脑功能和调节机制的有效手段,本研究提出经颅电刺激的人体平衡脑网络特征研究方法。招募24位被试在初级运动皮层施加伪/阳极/阴极经颅直流电刺激(tDCS),采集闭眼站立足底压力中心(COP)和脑电数据,对比分析COP特征和脑网络平均度、聚类系数、路径长度和全局效率等网络特征。结果表明,阳极tDCS致人体晃动频率变低,伪tDCS和阳极tDCS后的平均度、聚类系数、路径长度和全局效率分别为6.11±1.21、0.51±0.07、1.85±0.16、0.64±0.05和7.46±1.05、0.61±0.06、1.66±0.14、0.69±0.04,均存在显著性差异(P<0.05);阴极tDCS致晃动频率变高,平均度、聚类系数、路径长度和全局效率分别为5.51±1.33、0.43±0.07、1.95±0.16和0.62±0.04,与伪tDCS后相比差异显著(P<0.05)。研究表明,阳极tDCS有效激活运动皮层活性,增强全脑网络区间联系,提升了人体平衡能力;而阴极tDCS抑制了运动皮层活性,人体平衡能力趋弱。
Transcranial electrical stimulation is a neuromodulation technology with wide application potential,which still remains on the external manifestation in the research of human balance,and mechanisms of influence on the neuromodulation of human balance have not been clear yet.Brain functional network is an effective means to understand brain function and regulation mechanism.In this work,a method to study the features of human balanced brain network by transcranial electrical stimulation was proposed.There were 24 subjects recruited to apply sham/anodal/cathodal transcranial direct current stimulation(tDCS)in the primary motor cortex,and the planar center of pressure(COP)and EEG data were collected while standing with eyes closed,and the features of COP and the features of network including average degree,clustering coefficient,path length and global efficiency were compared and analyzed.Experimental results showed that anodal tDCS reduced human shaking frequency.The average degree,clustering coefficient,path length and global efficiency after sham tDCS and anodal tDCS were 6.11±1.21 and 0.51±0.07,1.85±0.16 and 0.64±0.05,7.46±1.05,0.61±0.06,1.66±0.14,0.69±0.04,respectively.There were significant differences in all groups(P<O.05).The shaking frequency was increased by cathodal tDCS,and the average degree,clustering coefficient,path length and global efficiency were 5.51±1.33,0.43±0.07,1.95±0.16 and 0.62±0.04,respectively,which were significantly different from those after sham tDCS(P<0.05).These results showed that anodal tDCS effectively activated the activity of motor cortex,enhanced the inter-interval connection of the whole brain network,and improved the balance ability of the human;while cathodal tDCS inhibited the activity of the motor cortex,and the balance ability of the human was weakened.
作者
蔡宏伟
罗志增
史红斐
Cai Hongwei;Luo Zhizeng;Shi Hongfei(Institute Intelligent Control and Robotics,School of Automation,Hangzhou Dianzi University,Hangzhou 310018,China;The Fourth Afiliated Hospital Zhejiang University School of Medicine,Jinhua 322000,Zhejiang,China)
出处
《中国生物医学工程学报》
CAS
CSCD
北大核心
2023年第4期394-402,共9页
Chinese Journal of Biomedical Engineering
基金
国家自然科学基金(62171171)
浙江省教育厅科研项目(Y202146756)。
关键词
经颅直流电刺激
平衡
脑网络
transcranial direct current stimulation
balance
brain network
