摘要
经颅电刺激(TES)是一种无创、经济、耐受性好的神经调控技术。但是,传统TES为全脑性刺激,且刺激电流较小,无法满足临床治疗中对深部脑区的有效聚焦刺激的需求。随着TES技术临床应用的不断深入,研究人员不断探索出新的刺激方法来提高刺激聚焦性、刺激强度和刺激深度,尤其是以高精度经颅电刺激、时间干涉刺激为代表的多电极刺激研究已展开。本文回顾了近年来TES的优化方案,并进一步分析了现有刺激方法的特点和局限,以期为相关临床应用提供借鉴和参考,并为后续研究提供指导。此外,本文还对TES未来发展趋势进行了展望,并提出了可能用于深脑刺激的TES优化方向,以期能为后续研究和应用提供新的思路。
Transcranial electric stimulation(TES)is a non-invasive,economical,and well-tolerated neuromodu-lation technique.However,traditional TES is a whole-brain stimulation with a small current,which cannot satisfy the need for effectively focused stimulation of deep brain areas in clinical treatment.With the deepening of the clinical application of TES,researchers have constantly investigated new methods for deeper,more intense,and more focused stimulation,especially multi-electrode stimulation represented by high-precision TES and temporal interference stimulation.This paper reviews the stimulation optimization schemes of TES in recent years and further analyzes the characteristics and limitations of existing stimulation methods,aiming to provide a reference for related clinical applications and guide the following research on TES.In addition,this paper proposes the viewpoint of the development direction of TES,especially the direction of optimizing TES for deep brain stimulation,aiming to provide new ideas for subsequent research and application.
作者
孟纬钰
张丞
吴昌哲
张广浩(综述)
霍小林(审校)
MENG Weiyu;ZHANG Cheng;WU Changzhe;ZHANG Guanghao;HUO Xiaolin(Beijing Key Laboratory of Bioelectromagnetism,Institute of Electrical Engineering,Chinese Academy of Sciences,Beijing 100190,P.R.China;School of Electrical,Electronics and Communications Engineering,University of Chinese Academy of Sciences,Beijing 100149,P.R.China)
出处
《生物医学工程学杂志》
EI
CAS
北大核心
2023年第5期1005-1011,共7页
Journal of Biomedical Engineering
基金
国家自然科学基金(51977205,52077209)。
关键词
经颅电刺激
强电流经颅交流电刺激
高精度电刺激
时间干涉刺激
交叉短脉冲刺激
Transcranial electric stimulation
Strong current-transcranial alternating current stimulation
High-definition electrical stimulation
Temporal interference stimulation
Intersectional short pulse stimulation
