摘要
【目的】分析云南省德宏傣族景颇族自治州(德宏州)≥50岁新报告HIV感染者中CD4^(+)T淋巴细胞计数水平及其影响因素,以了解其免疫状态和疾病进程,为今后制订艾滋病预防控制策略提供科学依据。【方法】利用全国综合防治信息系统数据,采用多因素logistic回归分析影响新报告HIV感染者首次CD4^(+)T淋巴细胞计数的因素。【结果】2016—2021年,德宏州≥50岁新报告HIV感染者642例,其中有CD4^(+)T淋巴细胞计数的571例,200例(35.0%)CD4^(+)T淋巴细胞计数<200个·μL^(-1)。多因素logistic回归发现,50~59岁年龄组、男性、离异或丧偶、文化程度较低者CD4^(+)T淋巴细胞计数<200个·μL^(-1)的风险较高。相比于自愿咨询检测者,强制或劳教戒毒人员检测出现CD4^(+)T淋巴细胞计数<200个·μL^(-1)的风险更低。【结论】2016—2021年德宏州≥50岁新报告HIV感染者例数无明显上升趋势,但CD4^(+)T淋巴细胞计数<200个·μL^(-1)的状况仍比较严重,应加强男性、中国籍、农民、汉族、已婚或离异、初中及以下文化程度、异性传播等重点人群的宣传,加强≥50岁人群的干预力度、提高检测效率。
[Objective]To investigate the factors that influence the first CD4^(+)T lymphocyte counts in newly reported HIV-infected cases aged50 and above in Dehong Prefecture of Yunnan Province during 2016 to 2021,and to understand the patient immune status and disease progression so as to provide scientific basis for HIV prevention and control strategies in the future.[Methods]Data was collected from the national HIV/AIDS information system.Multivariate logistic regression was used for the analysis of factors affecting the first CD4^(+)T lymphocyte counts.[Results]A total of 642 cases of HIV infection were newly reported,among them,571 cases had CD4^(+)T lymphocyte counts and 200cases(35.03%)had CD4^(+)T lymphocyte counts200 cells·μL~(-1).Patients who were in the 50-59 age group,male,divorced or widowed,and less educated were more likely to have CD4^(+)T lymphocyte counts200 cells·μL~(-1).Compared with active testing consultants,forced reeducation through labor or drug rehabilitation cases were less likely to have CD4^(+)T lymphocyte counts200 cells·μL~(-1).[Conclusion]There is no obvious upward trend in newly reported HIV infected persons aged 50 years and above in Dehong Prefecture during 2016 to 2021.However,the situation of CD4^(+)T lymphocyte counts200 cells·μL~(-1)is still serious.Attention should be paid to the key groups:male,Chinese nationality,farmers,Han nationality,married or divorced,junior high school education or below,and heterosexual transmission.It is necessary to strengthen the intervention in people aged 50 and above and improve the detection efficiency.
作者
周群博
吴烜赫
项丽芬
杨世江
叶润华
唐仁海
王继宝
杨跃诚
丁盈盈
何纳
段松
ZHOU Qunbo;WU Xuanhe;XIANG Lifen;YANG Shijiang;YE Runhua;TANG Renhai;WANG Jibao;YANG Yuecheng;DING Yingying;HE Na;DUAN Song(Department of STD and AIDS Prevention,Dehong Dai and Jingpo Autonomous Prefecture Center for Disease Control and Prevention,Mangshi,Yunnan 678400,China;Department of Epidemiology,School of Public Health,Key Laboratory of Public Health Safety,Ministry of Education,Fudan University,Shanghai 200032,China)
出处
《上海预防医学》
CAS
2023年第8期752-757,共6页
Shanghai Journal of Preventive Medicine
基金
国家科技重大专项(2018ZX10721102-004)。
