摘要
目的:探究并分析宜春市人民医院近三年肺炎克雷伯菌(Kpn)的临床分布及耐药变化趋势。方法:回顾性分析2020年1月—2022年12月宜春市人民医院住院患者各类临床标本分离出的Kpn菌株,共计387株,对菌株分布科室、标本类型及耐药情况进行研究分析。结果:近三年本院分离出的Kpn菌株在临床13个科室均有分布,其中占比居前三的是儿科、重症医学科、神经外科。儿科三年内检出Kpn的占比分别为19.66%、16.45%、16.10%;重症医学科三年内检出Kpn的占比分别为11.11%、14.47%、16.95%;神经外科三年内检出Kpn的占比分别为13.68%、13.16%、11.02%。近三年本院微生物室在10种类型标本中均分离出了Kpn菌株,其中占比较高的是痰液和血液;痰液三年内检出Kpn的占比分别为55.56%、58.55%、60.17%;血液(需氧瓶/厌氧瓶)三年内检出Kpn的占比分别为15.38%、17.11%、17.80%。另外,在脓液及尿液中检出Kpn的占比也较高。本院微生物室分离出的Kpn菌株对多种类型的抗生素存在不同程度的耐药,其中耐药情况最为严重的是头孢唑啉,2020—2022年的耐药率分别为41.03%、41.45%、44.07%;另外,氨苄西林/舒巴坦、氨曲南、呋喃妥因、复方磺胺甲噁唑、环丙沙星及头孢曲松也存在较为显著的耐药情况,耐药率普遍达到了30%以上;耐药率较低的抗生素包括厄他培南、美罗培南及莫西沙星。三年期间,Kpn耐药变化情况总体趋势较为平稳,未出现明显的耐药激增现象。结论:近三年,本院分离的Kpn菌株主要分布于儿科、重症医学科及神经外科,检出标本类型以痰液、血液标本居多。Kpn耐药变化趋势平稳,然而仍需要加强临床抗生素管理及使用规范,尽最大可能避免耐药情况加剧。
Objective:To explore and analyze the clinical distribution and change trend of drug resistance of Klebsiella pneumoniae(Kpn)in Yichun People's Hospital in recent three years.Method:A total of 387 Kpn strains isolated from various clinical specimens of inpatients in Yichun People's Hospital from January 2020 to December 2022 were retrospectively analyzed,and the distribution departments,specimen types and drug resistance of the strains were studied and analyzed.Result:In the past three years,Kpn strains isolated in our hospital were distributed in 13 clinical departments,among which the top three were Pediatrics Department,Critical Care Medicine Department,Neurosurgery Department.The Kpn cases detected in the Pediatrics Department within three years respectively accounted for 19.66%,16.45% and 16.10%.The Kpn detected in the Critical Care Medicine Department within three years respectively accounted for 11.11%,14.47% and 16.95%.The Kpn detected in the Neurosurgery Department within three years respectively accounted for 13.68%,13.16% and 11.02%.In the past three years,Kpn strains were isolated from 10 types of specimens in the microbiology room of our hospital,the relatively high proportion of which were sputum and blood.The Kpn detected in sputum within three years respectively accounted for 55.56%,58.55% and 60.17%.The Kpn detected in blood(aerobic bottle/anaerobic bottle)within three years respectively accounted for 15.38%,17.11% and 17.80%.In addition,the proportion of Kpn detected in pus and urine was also higher.Kpn strains isolated from the microbiology room of our hospital were resistant to various types of antibiotics to different degrees,among which Cefazolin was the most serious drug resistance,and the resistance rates from 2020 to 2022 respectively was 41.03%,41.45% and 44.07%.In addition,Ampicillin/Sulbactam,Aztreonam,Nitrofurantoin,Compound Sulfamethoxazole,Ciprofloxacin,and Ceftriaxone also had significant drug resistance,and the resistance rate generally reached more than 30%.Antibiotics with low re
作者
黄韬
谢璟
邬俊勇
吴雯
雷萌
徐荣
HUANG Tao;XIE Jing;WU Junyong;WU Wen;LEI Meng;XU Rong(Yichun People's Hospital,Jiangxi Province,Yichun 336000,China;不详)
出处
《中国医学创新》
CAS
2023年第29期165-169,共5页
Medical Innovation of China
关键词
肺炎克雷伯菌
临床分布
抗生素
耐药性
Klebsiella pneumoniae
Clinical distribution
Antibiotic
Drug resistance
