摘要
目的 对比分析严重少弱精子症患者血液和精液锌、钙、铜、铁4种微量元素含量,探讨该类患者微量元素失衡的相关性,拟定调理方案及时预防和治疗因微量元素失衡所致男性不育症。方法 回顾性分析2021年6月至2022年12月该院辅助生殖科收治的确诊为严重少弱精子症患者100例作为观察组,诊断标准根据世界卫生组织第5版精液常规分析标准操作规程文件标准,且排除遗传性疾病家族史。另选取100例精子质量正常的健康体检者作为对照组。2组研究对象纳入标准:(1)年龄25~40岁;(2)既往体健,无生殖系统疾病史;(3)睾丸、附睾及输精管无创伤疾病史;(5)最近6个月无服用含有上述微量元素药物史。结果 观察组患者血液和精液锌、钙含量均明显低于对照组(P<0.05),铁、铜含量均明显高于对照组,差异均有统计学意义(P<0.05)。观察组患者血液与精液锌含量存在直线关系(r=0.746,P=0.003)。结论 严重少弱精子症患者血液和精液微量元素含量对男性生殖能力意义重大,针对性的微量元素治疗有望改善该类患者的精子质量,从而借助现代辅助生殖技术达到良好的助孕结局。
Objective To compare and analyze the contents of zinc,calcium,copper and iron in blood and semen of patients with severe oligoasthenospermia,to explore the correlation between the imbalance of trace elements in these patients,and to formulate a conditioning plan to prevent and treat male infertility caused by the imbalance of trace elements in time.Methods A total of 100 patients with severe oligozoospermia diagnosed in the assisted reproductive department of the hospital from June 2021 to December 2022 were retrospectively analyzed as the observation group.The diagnostic criteria were based on the 5th edition of the World Health Organization standard operating procedures for routine semen analysis,and the family history of hereditary diseases was excluded.Another 100 healthy persons with normal sperm quality were selected as the control group.Inclusion criteria of two groups:(1)25-40 years old.(2)Previous health,no history of reproductive system disease.(3)No history of traumatic diseases in testis,epididymis and vas deferens.(4)No history of taking drugs containing the above trace elements in the last six months.Results The contents of zinc and calcium in blood and semen of control group were significantly lower than those in the control group(P<0.05),while the contents of iron and copper were significantly higher than those in the control group,with statistically significant differences(P<0.05).There was a linear correlation between zinc content in blood and semen zinc content in the observation group(r=0.746,P=0.003).Conclusion The content of trace elements in blood and semen of patients with severe oligozoospermia is of great significance to male reproductive ability.Targeted trace element treatment is expected to improve the sperm quality of such patients,so as to achieve a good pregnancy-assisted outcome with the help of modern assisted reproductive technology.
作者
张琴
苏占营
吴成亮
ZHANG Qin;SU Zhanying;WU Chengliang(Laboratory Department,Jiujiang Maternal and Child Health Hospital,Jiujiang,Jiangxi 332000,China;Assisted Reproductive Department,Jiujiang Maternal and Child Health Hospital,Jiujiang,Jiangxi 332000,China)
出处
《现代医药卫生》
2023年第20期3459-3462,共4页
Journal of Modern Medicine & Health
基金
江西省九江市科技局基金项目(S2022ZDYFN318)。
关键词
严重少弱精子症
微量元素
精浆
血液
相关性分析
Severe oligozoospermia
Trace element
Seminal plasma
Blood
Correlation anaysis
