摘要
目的 探究化疗联合阿帕替尼及调强放疗治疗中晚期宫颈癌老年患者临床效果。方法 以联勤保障部队第九○○医院收治的中晚期宫颈癌老年患者为研究对象,共计78例,时间为2018年12月—2020年12月,其中39例实施放化疗,作为对照组,39例实施化疗联合阿帕替尼及调强放疗,作为研究组,对比治疗效果。结果 研究组疾病控制率明显高于对照组,差异有统计学意义(P<0.05)。治疗后研究组患者免疫球蛋白A(IgA)水平高于对照组(P<0.05)。治疗后研究组患者丁淋巴细胞亚群CD4^(+)/CD8^(+)水平低于对照组(P<0.05)。治疗后研究组的肿瘤标志物癌胚抗原(CEA)水平、糖类抗原125(CA125)水平,糖类抗原19-9(CA19-9)水平均低于对照组P(<0.05)。研究组不良反应与对照组比较,差异无统计学意义(P>0.05)。结论 对中晚期宫颈癌老年患者采用化疗联合阿帕替尼及调强放疗,可缓解临床症状,提高患者免疫力,改善血清肿瘤标志物水平,且有效提高疾病控制率,且未增加不良反应,安全性高,治疗效果显著。
Objective To investigate the clinical effect of chemotherapy combined with apatinib and intensity modulated radiotherapy on elderly patients with advanced cervical cancer.Methods Admitted to the Joint Logistic Support Force 900 Hosital a total of 78 elderly patients with advanced cervical cancer were enrolled from December 2018 to December 2020.Among them,39 patients were treated with radiotherapy and chemotherapy as the reference group,and 39 patients were treated with chemotherapy combined with apatinib and intensity modulated radiotherapy as the study group,and the therapeutic effects were compared.Results The disease control rate of the study group was significantly higher than that of the reference group(P<0.05),the difference was statistically significant.The IgA level in the study group was higher than that in the reference group after treatment(P<0.05).The level of CD4^(+)/CD8^(+)in the study group was lower than that in the reference group after treatment(P<0.05).After treatment,CEA,CA125 and CA19-9 level in the study group were lower than those in the reference group(P<0.05).There was no statistical significance in toxicity and side effects between the study group and the reference group(P>0.05).Conclusion Chemotherapy combined with apatinib and intensity modulated radiotherapy can relieve clinical symptoms,improve immunity,and improve the level of tumor markers in serum in elderly patients with advanced cervical cancer,and effectively improve the disease control rate,less toxic and side effects,high safety,and significant therapeutic effect.
作者
黄晓燕
陈雄
李永青
Huang Xiaoyan;Chen Xiong;Li Yongqing(The Joint Logistic Support Force 900 Hospital,Fuzhou,Fujian 350000)
出处
《基层医学论坛》
2023年第28期16-18,共3页
The Medical Forum
关键词
中晚期宫颈癌
老年患者
化疗
阿帕替尼
调强放疗
Old age middle-late cervical cancer
Elderly patients
Chemotherapy
Apatinib
Intensity modulated radiotherapy
