摘要
目的评价调强放射治疗(IMRT)联合同步化疗治疗中晚期宫颈癌临床疗效及不良反应。方法应用随机平行对照法将80例中晚期宫颈癌患者分为两组。观察组采用IMRT+腔内近距离放疗+顺铂同步化疗;对照组采用常规放疗(前后对穿)+腔内近距离放疗+顺铂同步化疗。评价两组患者1年、3年、5年的局部控制率,远处转移率,患者生存率、无瘤生存率及不良反应。结果观察组1年、3年、5年局部控制率为100.0%、92.5%、87.5%。均高于对照组的95.0%、87.5%、70.0%。两组1年、3年的局部控制率,差异无统计学意义(P>0.05),观察组5年局部控制率明显高于对照组,差异有统计学意义(P<0.05)。观察组1年、3年、5年远处复发转移率与对照组相近(P>0.05)。观察组1、3、5年生存率分别为100.0%、95.0%、90.0%;均高于对照组的95.0%、92.5%、70.0%,两组1年、3年生存率,差异无统计学意义(P>0.05),观察组5年生存率明显高于对照组,差异有统计学意义(P<0.05)。观察组1、3、5年无瘤生存率分别为100%、75.0%、60.0%;均高于对照组的95.0%、67.5%、40.0%,观察组3年及5年无瘤生存率明显高于对照组,差异有统计学意义(P<0.05)。治疗组骨髓抑制、放射性膀胱炎、放射性直肠炎等不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论调强放射治疗联合同步化疗可提高晚期宫颈癌临床疗效,减少了治疗不良作用,明显改善患者的生活质量。
Objective To evaluate the clinical efficacy and adverse reactions of intensive modulated radiation therapy（ IMRT） combined with concurrent chemotherapy in treatment of patients with advanced cervical cancer. Methods A total of 80 hospitalized patients with advanced cervical cancer were divided into two groups according to random parallel control method. Patients in observation group were treated with intracavitary brachytherapy plus IMRT plus Cisplatin chemotherapy. Patients in control group were administrated by using conventional radiotherapy（ before and after wear） plus intracavitary brachytherapy and cisplatin concurrent chemotherapy. The efficacy of patients in these two groups had been evaluated with local control rates of 1 year,3 years and 5 years,and rates of distant metastasis,survival of patients,disease- free survival and adverse reactions. Results The 1- year,3- year and 5- year local control rates of patients in observation group were 100. 0%,92. 5% and 87. 5% respectively,and they were higher than those of 95. 0%,87. 5% and 70. 0% in patients of control group. The difference in one- year and 3 years local control rates was not statistically significant（ P〉0. 05）. The difference in 5- year local control rate between these 2 groups was statistically significant（ P〈0. 05）. The one year,three years and five- years distant recurrence rates in patients of observation group were similar to those of patients in control group（ P〉0. 05）. The 1 year,3 year and 5- year survival rates in patients of observation group were100. 0%,95. 0% and 90. 0% respectively; they were higher than those of 1 year,3 year and 5 year survival rates（ 95. 0%,92. 5% and 70. 0%） in patients of control group,and the difference was not statistically significant（ P〉0. 05）,and the difference in 3- year and five- year survival rates was statistically significant（ P〈0. 05）. The 1,3 and 5- year survival rates in patients of observation group were 100%,75. 0% and 60. 0% respectively; they were higher
出处
《临床和实验医学杂志》
2016年第1期51-54,共4页
Journal of Clinical and Experimental Medicine
关键词
宫颈癌
调强放疗
同步化疗
常规放疗
Cervical cancer
IMRT
Concurrent chemotherapy
Conventional radiotherapy
