摘要
目的:探讨多层螺旋CT联合蛋白S100A12预测诊断老年肺炎的临床意义。方法:选取医院收治的100例老年肺炎患者纳入老年肺炎组,另选同期在医院体检的100名健康老年人纳入健康对照组。两组均行多层螺旋CT和蛋白S100A12检测,对其一般临床资料、胸部CT征象和血清学指标水平进行分析,比较不同检查方法对老年肺炎诊断的灵敏度、特异度;采集血清标本后检测白细胞计数(WBC)、C反应蛋白(CRP)水平,采用酶联免疫吸附法检测血清钙结合蛋白S100A12水平,比较两组蛋白S100A12的水平差异;通过受试者工作特征(ROC)曲线评价多层螺旋CT联合蛋白S100A12诊断老年肺炎的预测价值。结果:老年肺炎组患者与健康对照组比较,血清WBC、CRP及蛋白S100A12较健康对照组明显升高,两组比较差异有统计学意义(t=13.996,t=23.046,t=138.89;P<0.05)。ROC曲线分析结果显示,多层螺旋CT的ROC曲线下面积(AUC)为0.801(95%置信区间0.750~0.852),预测老年肺炎的灵敏度为98.1%,特异度为73.9%;蛋白S100A12的AUC为0.760(95%置信区间0.707~0.812),预测老年肺炎的灵敏度为94.3%,特异度为78.2%;多层螺旋CT联合蛋白S100A12诊断的AUC为0.869,显著高于多层螺旋CT(0.801)、蛋白S100A12(0.760)单独检测。影像学特点显示,老年肺炎患者的CT影像学特征肺部表现以肺实质改变为主,肺内可见稍高密度的斑片状、蜂窝状或结节状影,边缘模糊,强化欠均匀,病灶内见小空洞影或含气支气管影,可见结节状影,边缘清晰。结论:多层螺旋CT联合蛋白S100A12可以预测诊断老年肺炎,而联合诊断的预测价值大于两种方法单独预测诊断价值。
Objective:To investigate the clinical significance of multi-slice spiral computed tomography(MSCT)combined with protein S100A12 in predicting and diagnosing senile pneumonia.Methods:A total of 100 senile patients with pneumonia admitted to hospital were selected as senile pneumonia group,and another 100 healthy senile persons who underwent physical examination in hospital during the same period were selected as the health control group.All of them underwent MSCT and protein S100A12 detection,and the generally clinical data,chest CT signs and serological indicators of them were retrospectively analyzed.The diagnostic sensitivity and specificity of different examination methods for senile pneumonia were compared.The white blood cell count(WBC)and C-reactive protein(CRP)of them were detected after the serum samples were collected.The enzyme linked immunosorbent assay(ELISA)was adopted to detect the serum calcium binding protein(S100A12),and the difference of the protein S100A12 between two groups was compared.The receiver operating characteristic(ROC)curve was used to evaluate the predictive value of MSCT combined with S100A12 in diagnosing senile pneumonia.Results:The serum WBC,CRP and protein S100A12 of senile pneumonia group were significantly higher than those of health control group,with statistical significance(t=13.996,t=23.046,t=138.89,P<0.05),respectively.The analysis results of ROC curve showed that the area under curve(AUC)of the ROC curve of MSCT was 0.801(95%confidence interval was 0.750-0.852,P<0.001),and the sensitivity and specificity of MSCT in predicting senile pneumonia were 98.1%and 73.9%,respectively.The AUC of protein S100A12 was 0.760(95%confidence interval was 0.707~0.812,P<0.001),and the sensitivity and specificity of that in predicting senile pneumonia were 94.3%and 78.2%,respectively.The AUC of MSCT combined with protein S100A12 was 0.869,which was significantly higher than that of single MSCT(0.801)and that of single protein S100A12(0.760).The imaging features showed that:the pulmonary ma
作者
马小民
刘自双
杜歌
张新峰
代敏
杨凯
MA Xiaomin;LIU Zi-shuang;DU Ge(Aged Rehabilitation Center,Beijing Rehabilitation Hospital Affiliated to Capital Medical University,Beijing 100144,China)
出处
《中国医学装备》
2023年第10期65-68,共4页
China Medical Equipment
基金
首都卫生发展科研专项(首发2020-4-2040)“S100A12在不同类型老年肺炎中的表达及作用研究”。
