摘要
熊果酸是一种五环三萜类化合物,存在于多种植物中,为极具潜力的中药成分,应用前景广阔。研究表明熊果酸有广泛药理活性,如通过激活caspase蛋白酶活性、调控Bcl-2蛋白表达水平诱导细胞凋亡,调节炎症因子NF-κB的活性及其免疫因子改善肿瘤相关炎症和微环境,对多种肿瘤细胞系发挥显著抗肿瘤作用。熊果酸还具有良好的抗菌作用及抗氧化作用。但由于其低溶解性、低渗透性导致其生物利用度低,新的药物剂型亟需进一步开发。本文就近年来熊果酸抗肿瘤、抗菌、抗氧化、新剂型等方面的研究发现进行梳理归纳。以期为其进一步深入研究及开发利用提供理论参考。
Ursolic acid is a kind of pentacyclic triterpenoid,which exists in a variety of plants and is a promising traditional Chinese medicine ingredient with broad application prospects.Previous studies have shown that ursolic acid has a wide range of pharmacological activities,such as inducing apoptosis by activating caspase protease activity,regulating the expression level of Bcl-2 protein,regulating the activity of inflammatory factor NF-κB and its immune factors to improve tumor-related inflammation and microenvironment,and exerting significant anti-tumor effects on a variety of tumor cell lines.Ursolic acid also has good antibacterial and antioxidant effects.However,due to its low solubility and low permeability,its low bioavailability requires further development of new drug dosage forms.This article summarizes the research findings of ursolic acid antitumor,antibacterial,antioxidant,and new dosage forms in recent years.In order to provide a theoretical reference for its further in-depth research and development and utilization.
作者
陈燕
何沙
陈春林
CHEN Yan;HE Sha;CHEN Chun-lin(College of Chemistry and Biological Engineering,Yichun University,Yichun 336000,China;The Drug Inspector Center of Jiangxi,Nanchang 330029,China)
出处
《宜春学院学报》
2023年第9期21-26,共6页
Journal of Yichun University
关键词
熊果酸
抗癌
抗菌
抗氧化
剂型
ursolic acid
anticancer
antibacterial
antioxidant
dosage form
