摘要
目的:探讨桂枝茯苓胶囊辅助治疗子宫内膜异位症(EMS)对血小板及血管生成的影响。方法:选取2020年1月-2022年3月本院确诊的120例EMS患者,随机数字表分为联合组和对照组各60例,对照组采取西医基础疗法,联合组在对照组基础上加用桂枝茯苓胶囊辅助治疗,疗程均为3个月经周期,对比两组治疗前后中医证候评分、痛经症状积分、血清糖类抗原125(CA125)、血管内皮生长因子(VEGF)、血管生成素-2(Ang-2)、血小板活化因子(CD62P、CD41)。结果:治疗后,两组中医证候主证、次证及总分均降低,联合组(8.63±2.20分、4.66±0.86分、13.29±2.50分)低于对照组(9.71±2.45分、5.42±1.34分、15.13±2.84分);血清CA125、VEGF、Ang-2水平均降低,且联合组(41.77±7.40 U/ml、154.3±17.5 ng/ml、43.96±6.57 ng/ml)低于对照组(45.84±7.95 U/ml、168.7±19.2 ng/ml、48.81±8.32 ng/ml);CD62P、CD41均降低,且联合组(11.62±3.54、42.75±7.04)%低于对照组(13.84±3.81、46.33±7.71)%;痛经VAS评分均降低,且联合组(3.85±0.92分)低于对照组(4.62±1.17分)(均P<0.05)。结论:桂枝茯苓胶囊辅助治疗EMS较单纯西医治疗能更有效改善患者临床症状,降低血小板活化程度及血管形成速度。
Objective:To explore the clinical effect and the mechanism of Guizhi fuling capsule for adjuvant treating patients with endometriosis(EMS).Methods:120 patients with EMS diagnosed in hospital from January 2020 to March 2022 were selected and were divided into two groups(60 cases in each group) by random number table.The patients in the control group were given treatment of western medicine for three menstrual cycles,and the patients in the study group were Guizhi fuling capsule combined with treatment of western medicine for three menstrual cycles.The TCM syndrome scores,the levels of serum carbohydrate antigen 125(CA125),vascular endothelial growth factor(VEGF),angiopoietin-2(Ang-2),platelet activating factor(CD62P and CD41) of the patients before and after treatment were compared between the two groups.Results:The main syndrome score,secondary syndrome score,and total score of the patients in the two groups after treatment had decreased significantly,and which(8.63±2.20 points,4.66±0.86 points,and 13.29±2.50 points) of the patients in the study group were significantly lower than those(9.71±2.45 points,5.42±1.34 points,and 15.13±2.84 points) of the patients in the control group.The levels of serum CA125,VEGF,and Ang-2 of the patients in the two groups after treatment had decreased significantly,and which(41.77±7.40U/ml,154.3±17.5ng/ml,and 43.96±6.57ng/ml) of the patients in the study group were significantly lower than those(45.84±7.95U/ml,168.7±19.2ng/ml,and 48.81±8.32 ng/ml) of the patients in the control group.The levels of both CD62P and CD41 of the patients in the two groups after treatment had decreased significantly,and which(11.62±3.54 and 42.75±7.04%) of the patients in the study group were significantly lower than those(13.84±3.81 and 46.33±7.71%)of the patients in the control group.The VAS score(3.85±0.92points)of the patients in the study group was significantly lower than that(4.62±1.17points)of the patients in the control group(all P<0.05).Conclusion:Compared with those of western
作者
刘钦文
王璇
王丽先
金洁琼
LIU Qinwen;WANG Xuan;WANG Lixian;JIN Jieqiong(Qingdao Jiaozhou Central Hospital,Shandong Province,266300)
出处
《中国计划生育学杂志》
2023年第10期2307-2310,2316,共5页
Chinese Journal of Family Planning
基金
2022-2024年青岛市医疗卫生重点学科建设项目资助。
