摘要
目的 检测并分析服用卡培他滨后出现手足综合征的结直肠癌患者血浆中主要炎症因子(IL-1β、IL-6、IL-10、IL-12、IL-17、IL-23、TNF-α、IFN-γ、CPR和CCL-5)与手足综合征之间的相关性。方法 收集35例服用卡培他滨的结直肠癌患者血浆样本,根据手足综合征分级诊断标准对其轻重程度进行划分,用ELISA试剂盒检测血浆中各炎症因子的含量。结果 所有炎症因子的标准曲线呈线性(r>0.990 0),并测定了不同结直肠癌患者血浆中炎症因子的含量,其中,TNF-α含量水平变化较为明显,且具有参考价值。结论 不同的炎症因子在不同分级的手足综合征患者血浆中浓度存在一定差异,且TNF-α炎症因子含量水平与其发生手足综合症的轻重程度密切相关。
Objective To investigate the correlation between plasma inflammatory factors[IL-1β,IL-6,IL-10,IL-12,IL-17,IL-23,TNF-α,TGF-β,IFN-γ,C-reactive protein(CPR)CCL-5]and hand-foot syndrome in colorectal cancer patients after taking capecitabine.Methods 35 colorectal cancer patients treated with capecitabine were collected and the degree of severity was divided according to the hand-foot syndrome grading diagnostic criteria.The concentrations of inflammatory factors in plasma were determined by ELISA kits.Results The standard curve of all inflammatory cytokines were linear(r>0.9900),and plasma concentrations of inflammatory cytokines in patients with colorectal cancer were determined.The concentration of TNF-αchanged obviously,which had reference value.Conclusion The concentrations of different inflammatory factors were different and the concentration of TNF-αwas closely correlated with the severity of hand-foot syndrome.
作者
刘艳平
王志鹏
崔莉莉
许封菁
张蒙伟
高守红
LIU Yanping;WANG Zhipeng;CUI Lili;XU Fengjing;ZHANG Mengwei;GAO Shouhong(Department of Pharmacy,Changzheng Hospital,Naval Medical University,Shanghai 200003,China;Bioengineering Research Institute of Yichun University,Yichun 336000,China)
出处
《药学实践与服务》
CAS
2023年第10期634-637,共4页
Journal of Pharmaceutical Practice and Service
关键词
结直肠癌
卡培他滨
手足综合征
炎症因子
colorectal cancer
capecitabine
hand-foot syndrome
inflammatory factors
