摘要
目的探讨甘露糖结合凝集素相关的丝氨酸蛋白酶2(MASP-2)、结肠癌转移相关基因1(MACC1)联合微小RNA-17(miR-17)对结肠癌腹腔镜全结肠系膜切除术(CME)患者的预后评估价值。方法选取2018年3月至2020年3月郑州市第七人民医院收治的80例结肠癌患者,均接受CME治疗。随访3 a,根据预后情况分组,对比不同预后患者血清MASP-2、MACC1、miR-17水平。分析影响预后的因素及MASP-2、MACC1、miR-17预测结肠癌CME患者的预后评估价值。结果结肠癌患者术后血清MACC1、miR-17水平低于术前,MASP-2水平高于术前(P<0.05)。随访3 a,80例结肠癌CME患者中19例被纳入预后不良组,60例被纳入预后良好组。预后不良组临床分期Ⅲ期占比及血清MACC1、miR-17水平均高于预后良好组,MASP-2水平低于预后良好组(P<0.05)。血清MACC1、miR-17是影响结肠癌CME预后的独立危险因素,MASP-2为保护因素(P<0.05)。血清MASP-2、MACC1、miR-17均可预测结肠癌CME患者的预后,三者联合预测价值最高(P<0.05)。结论结肠癌CME后患者血清MACC1、miR-17水平降低,MASP-2水平升高,上述指标均可作为结肠癌CME预后的预测指标,且三者联合的预后评估价值最高。
Objective To investigate the prognostic value of mannose associated serine protease 2(MASP-2),metastasis-associated in colon cancer 1(MACC1)combined with microRNA-17(miR-17)in the prognostic assessment of complete mesocolic excision(CME)for colon cancer.Methods From March 2018 to March 2020,80 patients with colon cancer were selected from the Seventh People’s Hospital of Zhengzhou,all of whom received CME treatment.The patients were followed up for 3 years,and were divided into groups according to the prognosis.The levels of serum MASP-2,MACC1 and miR-17 in patients with different prognosis were compared.The prognostic factors and the prognostic value of MASP-2,MACC1 and miR-17 in patients with colon cancer CME was analyzed.Results The levels of serum MACC1 and miR-17 in patients with colon cancer after operation were lower than those before operation,and the level of MASP-2 was higher than that before operation(P<0.05).The patients were followed up for 3 years,of the 80 patients with colon cancer CME,19 patients were included in the poor prognosis group and 60 patients were included in the good prognosis group.The proportion of clinical stageⅢand the levels of serum MACC1 and miR-17 in the poor prognosis group were higher than those in the good prognosis group,while the level of MASP-2 was lower than that in the good prognosis group(P<0.05).Serum MACC1 and miR-17 were independent risk factors for the prognosis of CME in colon cancer,and MASP-2 was a protective factor(P<0.05).Serum MASP-2,MACC1 and miR-17 can all predict the prognosis of patients with colon cancer CME,and their combined predictive value was the highest(P<0.05).Conclusion After colon cancer CME,the serum levels of MACC1,miR-17 decreased,while the level of MASP-2 increased.All the above indexes can be used as prognostic indicators of colon cancer CME,and the combination of them has the highest prognostic value.
作者
马剑锋
黑涛
赵正国
刘景华
MA Jianfeng;HEI Tao;ZHAO Zhengguo;LIU Jinghua(The First Ward of General Surgery,the Seventh People’s Hospital of Zhengzhou,Zhengzhou 450000,China;Department of Gastroenterology,the Seventh People’s Hospital of Zhengzhou,Zhengzhou 450000,China)
出处
《河南医学研究》
CAS
2023年第19期3517-3521,共5页
Henan Medical Research
