摘要
革兰阴性杆菌(GNB)在临床致病菌中的分离率较高,会造成患者呼吸道、泌尿道等感染及败血症的发生,使患者的痛苦增加并且延长住院时间。碳青霉烯类药物是目前临床上已经被广泛使用的β-内酰胺类抗菌药物。随着这类药物的使用越来越多,对其耐药的GNB不断增加,甚至出现更为严重的多重耐药菌,造成了临床抗感染药物的选择和医院内感染控制的难度进一步加大,增加了临床治疗难度。研究显示,菌株产生的耐药基因在不同国家、地区和不同菌株中均有差异。该文主要对不同种类碳青霉烯类耐药的革兰阴性杆菌(CRO)产生的碳青霉烯酶种类和耐药基因的分布及相应的检测方法进行综述,为CRO的治疗、预防及医院内感染的控制提供数据支持。
Gram-negative bacilli(GNB)has a high isolation rate among clinical pathogenic bacteria,which may cause the occurrence of respiratory tract,urinary tract infection and septicemia,increase the patient's pain and prolong the hospital stay.Carbapenems drugs are widely usedβ-lactam antibacterial agents in clinic.With the increasing use of such drugs,GNB resistant to them is increasing,and even more serious multi-drug resistant bacteria appear,which results in the difficulty further increase of clinical anti-infective drugs selection and the infection control in hospital,and increases the difficulty of clinical treatment.The studies show that the resistance genes produced by strains were different in different countries,regions and bacterial strains.This paper reviews the types of carbapenase produced by different carbapenem resistant Gram-negative bacteria(CRO),the distribution of drug resistance genes and the corresponding detection methods to provide the data support for the treatment,prevention and nosocomial infection control of CRO.
作者
张晓静
孟祥璐(综述)
李静(审校)
ZHANG Xiaojing;Meng Xianglu;LI Jing(Department of Pharmacy and Laboratory Medicine,Heze Medical College,Heze,Shandong 274000,China;Department of Pathogenic Biology,School of Basic Medicine,Qingdao University,Qingdao,Shandong 266021,China;Department of Clinical Laboratory,Yuncheng County People's Hospital,Heze,Shandong 274700,China;Department of Clinical Laboratory,Laoshan Branch Hospital,Affiliated Hospital of Qingdao University,Qingdao,Shandong 266035,China)
出处
《检验医学与临床》
CAS
2023年第19期2906-2911,共6页
Laboratory Medicine and Clinic
基金
青岛大学附属医院院级项目(QDFY201929)。
关键词
革兰阴性杆菌
碳青霉烯类耐药
耐药基因
Gram-negative bacillus
Carbapenem resistance
drug resistance gene
