摘要
目的比较重复低强度红光照射和0.01%低浓度阿托品对儿童青少年近视的防控效果。方法回顾性病例对照研究。纳入苏州大学理想眼科医院2020年4月至2021年4月儿童青少年近视160例(320只眼),年龄8~14岁。所有受试者均配戴普通框架眼镜,按不同方式分为3组:A组,重复低强度红光照射60例(120只眼);B组,0.01%阿托品滴眼液组50例(100只眼);另选50例(100只眼)为C组,对照组。随访12个月,分析等效球镜屈光度(SE)及眼轴长度。结果应用后6个月及12个月的SE:A组分别为(-2.60±2.76)D及(-2.84±1.53)D,明显低于B组的(-3.19±1.36)D、(-3.56±1.35)D和C组的(-4.02±1.22)D、(-4.91±1.18)D,总体差异均具有统计学意义(F_(时间)=906.56,F_(组别)=17.24,F_(时间×组别)=1096.98;均P<0.001);B组明显低于C组,差异具有统计学意义(P<0.05)。眼轴长度:A组的(24.84±1.02)mm,(24.87±0.99)mm明显低于B组的(25.15±0.77)mm,(25.31±0.76)mm和C组的(25.14±0.87)mm,(25.36±0.84)mm,差异均具有统计学意义(F_(时间)=203.95,F组别=3.18,F_(时间×组别)=315.14;P<0.001,P=0.043,P<0.001),B、C两组间差异无统计学意义(P>0.05)。结论重复低强度红光照射及0.01%阿托品滴眼液均能有效控制青少年近视度数进展和眼轴增长。而重复低强度红光照射控制眼轴增长的效果更优。
Objective To compare the efficacy of repeated low-level red light irradiation and 0.01%atropine eye drops on prevention and control of myopia in children and adolescents.Methods This was a retrospective case-control study.A total of 320 eyes of 160 children and adolescents with myopia who were admitted to the Lixiang Eye Hospital of Soochow University from Apr.2020 to Apr.2021 were included,and the average age was 8-14 years.All subjects wore ordinary glasses and they were divided into three groups based on different methods.Group A,120 eyes of 60 cases,received repeated low-level red light irradiation treatment.Group B,100 eyes of 50 cases was treated with 0.01%atropine eye drops.Group C was consisted of 100 eyes of 50 cases as the control group.They were followed up for 12 months to analyze the refractive status of the eyes,the diopter of spherical equivalent(SE)and axial length.Results At 6 and 12 months of follow-up after treatment,SE of group A were(-2.60±2.76)D and(-2.84±1.53)D,which were significantly lower than(-3.19±1.36)D and(-3.56±1.35)D of group B and the(-4.02±1.22)D,and(-4.91±1.18)D of group C.The differences were statistically significant(Ftime=906.56,Fgroups=17.24,Finteractive=1096.98;all P<0.001).Group B resulted significantly lower than group C.The difference was statistically significant(P<0.05).Axial length:the(24.84±1.02)mm and(24.87±0.99)mm of group A were significantly lower than the(25.15±0.77)mm and(25.31±0.76)mm of group B and the(25.14±0.87)mm and(25.36±0.84)mm of group C(F_(time)=203.95,F_(groups)=3.18,F_(interactive)=315.14;P_(time)<0.001,P_(groups)=0.043,P_(interactive)<0.001).There was no significant difference between group B and group C(P>0.05).Conclusion Repeated low-level red light irradiation and using of 0.01%atropine eye drops can effectively postpone the progression of myopia in children and adolescents.Repeated low-level red light irradiation can significantly control the growth of axial length and the efficacy is better.
作者
马根方
颜世传
赵光辉
王坤
Ma Genfang;Yan Shichuan;Zhao Guanghui;Wang Kun(Department of Strabismus and Pediatric Ophthalmology,the Lixiang Eye Hospital of Soochow University,Suzhou 215000,China)
出处
《中华眼外伤职业眼病杂志》
2023年第8期561-565,共5页
Chinese Journal of Ocular Trauma and Occupational Eye Disease
