摘要
目的研究慢性肾功能衰竭合并肾性骨营养不良患者应用血液透析联合血液灌流治疗的临床效果。方法将2020年9月—2022年9月丰县人民医院收治的慢性肾功能衰竭合并肾性骨营养不良患者共86例,根据随机数表法分为两组,每组43例。对照组应用血液透析治疗,观察组予血液透析联合血液灌流。比较两组临床疗效、治疗前后肾功能及血清血磷、血钙、甲状旁腺激素水平、不良事件发生情况。结果观察组的好转率为90.70%,高于对照组的72.09%,差异有统计学意义(χ^(2)=4.914,P<0.05)。治疗后两组患者的血肌酐(serum creatinine concentration,Scr)、血尿素氮(blood urea nitrogen,BUN)、β_(2)-微球蛋白(β_(2)-Microglobulin,β_(2)-MG)水平显著下降,差异有统计学意义(P<0.05);与对照组比较,观察组患者治疗后血清Scr、BUN、β_(2)-MG水平更低,差异有统计学意义(P<0.05);治疗后,两组患者的血磷水平显著下降,血钙水平显著升高,且观察组血磷更低,差异有统计学意义(P<0.05);治疗后,观察组甲状旁腺激素(parathyroid hormone,PTH)的水平显著降低,且显著低于对照组,差异有统计学意义(P<0.05);另外,在不良事件发生率比较上,观察组低于对照组,差异有统计学意义(P<0.05)。结论应用血液透析联合血液灌流治疗慢性肾功能衰竭合并肾性骨营养不良患者的临床疗效更高,安全性高,能有效改善患者血清钙、磷以及甲状旁腺激素水平,值得临床推广。
Objective To study the clinical effect of hemodialysis combined with hemoperfusion in patients with chronic renal failure and renal osteodystrophy.Methods A total of 86 patients with chronic renal failure combined with renal osteodystrophy who were admitted to Fengxian People's Hospital from September 2020 to September 2022 were divided into two groups according to the random number table method,with 43 cases in each group.The control group was treated with hemodialysis,and the observation group was treated with hemodialysis combined with hemoperfusion.The clinical efficacy,renal function,serum phosphorus,blood calcium,parathyroid hormone levels,and occurrence of adverse events before and after treatment were compared between the two groups.Results The improvement rate of the observation group was 90.70%,which was higher than 72.09% of the control group,and the difference was statistically significant(χ^(2)=4.914,P<0.05).After treatment,the serum creatinine concentration(Scr),blood urea nitrogen(BUN),andβ2-microglobulin(β_(2)-MG)levels of the two groups of patients decreased significantly,and the difference was statistically significant(P<0.05).Compared with the control group,the serum Scr,BUN,and β_(2)-MG levels of patients in the observation group were lower after treatment,and the difference was statistically significant(P<0.05).After treatment,the blood phosphorus levels of the two groups of patients were significantly reduced,and the blood calcium levels were significantly increased,and the observation group had lower blood phosphorus,the difference was statistically significant(P<0.05).After treatment,the level of parathyroid hormone(PTH)in the observation group was significantly reduced,and significantly lower than that in the control group,the difference was statistically significant(P<0.05).In addition,the incidence rate of adverse events in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The application of hemodialysi
作者
孙保党
SUN Baodang(Department of Nephrology,Fengxian People's Hospital,Fengxian,Jiangsu Province,221700 China)
出处
《系统医学》
2023年第14期93-96,共4页
Systems Medicine
