摘要
目的探讨那屈肝素钙对高龄复发性流产患者子宫动脉血流及妊娠结局的影响。方法选取2018年1月—2022年12月丽水市中医院收治的120例高龄复发性流产患者为研究对象,按随机数字表法分为治疗组和对照组,每组各60例。对照组使用常规保胎治疗,治疗组除常规保胎治疗外,加用那屈肝素钙皮下注射。观察两组患者治疗前后子宫动脉血流动力学参数[阻力指数(resistance index,RI)、搏动指数(pulsatility index,PI)、收缩末期最大流速/舒张末期最大流速(S/D)]、妊娠结局及不良反应。结果对照组治疗前RI为(0.84±0.05)、PI为(2.35±0.37)、SD为(7.31±2.59),治疗后RI为(0.86±0.08)、PI为(2.41±0.44)、SD为(7.14±3.00),经t检验,治疗后RI、PI、SD与治疗前相比,差异均无统计学意义(均P>0.05);治疗组治疗前RI为(0.85±0.04)、PI为(2.43±0.33)、SD为(7.35±1.97),治疗后RI为(0.77±0.08)、PI为(1.99±0.46)、SD为(4.96±1.63),经t检验,治疗后RI、PI、SD均显著低于治疗前,差异均有统计学意义(均P<0.05)。治疗组活产率(80.00%)显著高于对照组(41.66%),差异有统计学意义(χ^(2)=18.502,P<0.05);治疗组早产发生率为10.41%,对照组早产发生率为4.00%,差异无统计学意义(P>0.05);两组均未发生新生儿死亡及明显先天畸形。两组患者中均存在轻微不良反应,停药后恢复正常,治疗组和对照组的药物不良反应发生率分别为10.00%和6.67%,差异无统计学意义(P>0.05)。结论那屈肝素钙治疗高龄复发性流产效果显著,可有效降低子宫动脉血流阻力,改善患者的妊娠结局,且不良反应轻微,值得临床推广应用。
Objective To investigate the efect of nadroparin calcium on uterine artery blood flow and pregnancy outcome in elderly pregnant women with reeurent spontaneous abortion.MethodsFrom January 2018 to December 2022,120 cases of elderly pregnant women with recurrent spontaneous abortion were selected from Lishui Hospital of Traditional Chinese Medicine.They were randomly divided into con-trol group and treatment group,with 60 cases in each group.The control group was treated with routine fetal protection therapy,while the treatment group was treated with nadroparin calcium subcutaneous injection in addition to routine fetal protection therapy.The changes of the uterine artery Hemodynamics parameters(RI,PI and SD),pregnancy outcome and adverse reactions were observed before and afer treat-ment.Results In the control group,RI was(0.84±0.05),PI was(2.35±0.37),SD was(7.31±2.59)before treatment,RI was(0.86±0.08),PI was(2.41±0.44),SD was(7.14±3.00)after treatment.There was no significant difference in RI,PI and SD be-tween before and after treatment in the control group(P>0.05).In the treatment group,RI,PI and SD were(0.85±0.04),(2.43±0.33)and(7.35±1.97)respectively before treatment.RI,PI and SD were(0.77±0.08),(1.99±0.46)and(4.96±1.63)respectively after treatment.By t-test,RI,PI and SD after treatment were significantly lower than those before treatment(P<0.05).The live birth rate(80%)in the treatment group was significantly higher than that(41.66%)in the control group(x=18.502,P<0.05).The premature birth rate was 10.41%in the treatment group and 4%in the control group,there was no staltistical significance(P>0.05).No Perinatal mortality or congenital malformation occurred in either group.There were slight adverse reactions in both groups,which return to normal after withdrawal.The adverse reaction rate was 10%in the treatment group and 6.67%in the control group,there was no statistical significance(P>0.05).Conclusion Nadroparin calcium is effective in the treatment of elderly pregnant women with recurrent spon
作者
方圆
叶咏菊
江伟华
FANG Yuan;YE Yong-ju;JIANG Wei-hua(Department of Obstetrics and Gynecology,Lishui Hospital of Traditional Chinese Medicine,Lishui,Zhejiang 323000,China)
出处
《中国妇幼保健》
CAS
2023年第19期3714-3717,共4页
Maternal and Child Health Care of China
基金
浙江省中医药科技计划项目(2023ZL800)。
关键词
高龄
复发性流产
那屈肝素钙
子宫动脉血流
妊娠结局
Elderly pregnant women
Recurrent spontaneous abortion
Nadroparin calcium
Uterine artery blood flow
Pregnancy out-come
