摘要
目的:探索影响原发性肾病综合征微小病变(MCD)青年患者浆膜腔积液及其严重程度的相关因素。方法:回顾性分析75例青年MCD患者的临床资料,根据是否有浆膜腔积液分为有浆膜腔积液组(n=45)和无浆膜腔积液组(n=30);根据浆膜腔积液严重程度分为少量浆膜腔积液组(n=19)、中量浆膜腔积液组(n=9)和大量浆膜腔积液组(n=17);根据浆膜腔积液累及浆膜腔个数分为1个浆膜腔积液组(n=18)、2个浆膜腔积液组(n=21)和3个浆膜腔积液组(n=6)。比较各组间血浆白蛋白、24 h尿蛋白定量、血脂、肾功能、甲状腺功能、免疫球蛋白、补体、中性粒细胞及淋巴细胞水平、凝血功能、有无合并感染等;多因素Logistic回归分析影响MCD患者浆膜腔积液及其严重程度的相关因素。结果:IgG、D-二聚体均是青年MCD患者浆膜腔积液的独立影响因素(P<0.05)。血浆白蛋白是青年MCD患者浆膜腔积液量大小的独立影响因素(P<0.05)。补体C3是青年MCD患者浆膜腔积液累及腔数的独立影响因素(P<0.05)。结论:高D-二聚体、低IgG是原发性MCD青年患者浆膜腔积液的独立危险因素,低白蛋白血症、补体C3降低是原发性MCD青年患者浆膜腔积液严重程度的独立危险因素。
Objective:To investigate the related clinical factors that affect formation and severity degree of serous cavity effusion in young patients with minimal change disease(MCD)of primary nephrotic syndrome.Methods:The clinical data of 75 young patients with MCD were retrospective analysed.According to whether there was serous cavity effusion,they were divided into the serous cavity effusion group(n=45)and the without serous cavity effusion group(n=30).According to the severity of serous cavity effusion,they were divided into a small amount of serous cavity effusion group(n=19),a moderate amount of serous cavity effusion group(n=9),and a large amount of serous cavity effusion group(n=17).According to the number of serous cavities affected by serous cavity effusion,they are divided into 1 serous cavity effusion group(n=18),2 serous cavity effusion groups(n=21),and 3 serous cavity effusion groups(n=6).The plasma albumin,24 hour urine protein quantification,blood lipids,renal function,thyroid function,immunoglobulins,complements,neutrophils,lymphocytes,coagulation function and infection situation were compared between groups.Multivariate Logistic regression analysis was used to identify the relevant factors that affect the severity of serous fluid accumulation in MCD patients.Results:IgG and D-dimer were independent influencing factors for serous cavity effusion in young MCD patients(P<0.05).Plasma albumin was an independent influencing factor for the volume of serous cavity effusion in young MCD patients(P<0.05).C3 was an independent influencing factor for the number of serous cavity in young MCD patients(P<0.05).Conclusion:High D-dimer and low IgG are independent risk factors for serous cavity effusion in young MCD patients.Hypoalbuminemia and low C3 are independent risk factors for the severity of serous cavity effusion in young MCD patients.
作者
程琳
陈怡渝
郑兰兰
黄朝晖
高勤
何常
CHENG Lin;CHEN Yi-yu;ZHENG Lan-lan;HUANG Zhao-hui;GAO Qin;HE Chang(0x09Department of Clinical Medicine,Guizhou Medical University,the Affiliated Hospital of Guizhou Medical University,Guiyang 550004,Guizhou,China;Department of Nephrology,the Affiliated Hospital of Guizhou Medical University,Guiyang 550004,Guizhou,China;Department of Pathology,the Affiliated Hospital of Guizhou Medical University,Guiyang 550004,Guizhou,China)
出处
《川北医学院学报》
CAS
2023年第9期1250-1255,共6页
Journal of North Sichuan Medical College
关键词
肾病综合征
微小病变
浆膜腔积液
LOGISTIC回归分析
Primary nephrotic syndrome
Minimal change disease
Serous cavity effusion
Logistic regression analysis
