摘要
目的探讨同型半胱氨酸、纤维蛋白原、D-二聚体与初发性急性脑梗死严重程度的相关性。方法选择2022年1月至2022年12月福建医科大学附属协和医院神经内科初发急性脑梗死患者129例,根据美国国立卫生院卒中量表(NIHSS)评分对病情严重程度进行分类,分为轻度脑梗死组和中重度脑梗死组,通过logistic回归分析性别、年龄、血清同型半胱氨酸、纤维蛋白原、D-二聚体与初发急性脑梗死严重程度的相关性,通过ROC曲线分析纤维蛋白原、D-二聚体对初发性急性脑梗死严重程度的预测价值。结果年龄、同型半胱氨酸与初发急性脑梗死严重程度无相关性(P>0.05),性别、纤维蛋白原、D-二聚体与初发急性脑梗死严重程度有相关性(P<0.05);纤维蛋白原、D-二聚体对初发性急性脑梗死严重程度具有预测价值。其中,纤维蛋白原的AUC为0.622,P<0.05;D-二聚体的AUC为0.663,P<0.05。结论纤维蛋白原、D-二聚体是影响初发性急性脑梗死严重程度的危险因素,二者对初发性急性脑梗死的严重程度具有预测价值,临床应关注初发性急性脑梗死患者的凝血指标变化情况,结合患者病情严重程度给予针对性干预治疗,以降低急性脑梗死的致残率,提高患者生活质量。
Objective To explore the correlation between homocysteine,fibrinogen,D-dimer and the severity of primary acute cerebral infarction.Methods From January 2022 to December 2022,129 patients with initial acute cerebral infarction in Neurology,Union Hospital Affiliated to Fujian Medical University were selected.The severity of the disease was classified into mild cerebral infarction group and moderate to severe cerebral infarction group according to the NIHSS score.The gender,age,serum homocysteine,fibrinogen The correlation between D-dimer and the severity of primary acute cerebral infarction.The predictive value of fibrinogen and D-dimer on the severity of primary acute cerebral infarction was analyzed by Receiver operating characteristic.Results The correlation between age,homocysteine and the severity of initial acute cerebral infarction was not significant(P>0.05),while gender,fibrinogen and D-dimer were correlated with the severity of initial acute cerebral infarction(P<0.05).The fibrinogen and D-dimer can predict the severity of primary acute cerebral infarction.Among them,the AUC of fibrinogen was 0.622,P<0.05,and the AUC of D-dimer was 0.663,P<0.05.Conclusions Fibrinogen and D-dimer are risk factors that affect the severity of primary acute cerebral infarction,and they have predictive value for the severity of primary acute cerebral infarction.Attention should be paid to the changes of coagulation indicators in patients with primary acute cerebral infarction,and targeted intervention should be given in combination with the severity of patients'condition to reduce the disability rate of acute cerebral infarction and improve the quality of life of patients.
作者
李敏
林增榕
LI Min;LIN Zengrong(Department of Internal Medicine,Hospital of Fujian Normal University,Fuzhou 350007,China;Department of Medical Record,Union Hospital Affiliated to Fujian Medical University,Fuzhou 350001,China)
出处
《中国医药指南》
2023年第28期95-98,共4页
Guide of China Medicine
