摘要
目的探讨解郁丸联合艾地苯醌治疗脑卒中后抑郁的效果。方法抽取2020年1月至2021年12月平顶山市第一人民医院收治的脑卒中后抑郁患者82例,按随机数字表法分为对照组与研究组,每组41例。两组均给予常规治疗,对照组在常规治疗基础上给予艾地苯醌治疗,研究组在对照组基础上联合解郁丸治疗。比较两组治疗后的神经功能、抑郁症状评分、脑血流情况、P13K/Akt信号通路蛋白水平、疗效及不良反应发生情况。结果治疗后,两组美国国立卫生研究院卒中量表(NIHSS)评分与汉密尔顿抑郁量表(HAMD)评分均下降,且研究组评分低于对照组(P<0.05);治疗后,两组脑血流量、脑血流速度提高,通过时间减少,且研究组优于对照组(P<0.05)。治疗后,两组P13K、pAKT、Bax水平下降,Bcl水平上升,且研究组各水平变化优于对照组(P<0.05)。研究组有效率(90.24%,37/41)高于对照组(70.73%,29/41),P<0.05。两组恶心、口干、便秘、头痛等不良反应发生率比较差异未见统计学意义(P>0.05)。结论解郁丸联合艾地苯醌能有效改善脑卒中后抑郁患者的神经功能与抑郁症状,提升脑血流量与速度,可能与介导P13K/Akt信号通路激活有关。
Objective To investigate the therapeutic effect of Jieyu pill combined with idebenone on post-stroke depression.Methods Eighty-two patients with post-stroke depression treated in Pingdingshan First People’s Hospital from January 2020 to December 2021 were selected,and they were divided into control group and research group by random number table methods,with 41 cases in each group.Both groups received conventional therapy;the control group was treated with adibenzoquinone on the basis of routine treatment,while the research group was treated with Jieyu pill based on the treatment of the control group.Then,the neurological function,depressive symptoms,cerebral blood flow,P13K/Akt signal pathway related proteins,clinical efficacy and adverse reactions were compared between the two groups.Results After treatment,the scores of National Institutes of Health stroke scale(NIHSS)and Hamilton depression scale(HAMD)of the two groups decreased,and the study group had lower scores than the control group(P<0.05).After treatment,the cerebral blood flow and cerebral blood flow velocity of the two groups increased,and the passage time decreased,moreover,the above indexes in the research group were superior to those in the control group(P<0.05).After treatment,the levels of P13K,pAKT,and Bax in both groups decreased,while the level of Bcl in the two groups increased,and the change in each index in the study group was superior to that in the control group,corresponding(P<0.05).The effective rate of the research group(90.24%,37/41)was higher than that of the control group(70.73%,29/41),P<0.05.There was no statistically significant difference in the incidence of adverse reactions,such as nausea,dry mouth,constipation,and headache,between the two groups(P>0.05).Conclusions Jieyu pill combined with idebenone in the treatment of post-stroke depression can effectively improve the neurological function,alleviate depressive symptoms,and ameliorate the cerebral blood flow and velocity,which may be related to the activation of P13K/Akt si
作者
胡洁滨
朱晓威
高露
Hu Jiebin;Zhu Xiaowei;Gao Lu(Department of Neurology,Pingdingshan First People’s Hospital,Pingdingshan 467000,China)
出处
《中国实用医刊》
2023年第12期120-122,F0003,共4页
Chinese Journal of Practical Medicine
