摘要
目的探讨持续性心房颤动(PsAF)射频消融术(RFA)中伊布利特的应用效果。方法抽取2019年6月至2022年6月焦作市人民医院收治的80例PAF患者进行研究,以双色球法分为对照组和观察组,每组40例。对照组采用RFA,观察组在对照组治疗基础上加用伊布利特。比较两组的成功转复率、复律时间、QTc达峰值时间,比较两组手术前后心肌损伤标志物水平、AA间期与QTc间期,比较两组不良反应发生率与随访1周的复发情况。结果观察组成功转复率(75.00%,30/40)高于对照组(52.50%,21/40),复律时间、QTc达峰值时间均少于对照组,差异有统计学意义(P<0.05)。术前,两组心肌损伤标志物水平比较差异未见统计学意义(P>0.05);术后,观察组心肌损伤标志物水平均优于对照组(P均<0.05)。手术前后,两组AA间期与QTc间期比较差异均未见统计学意义(P均>0.05)。两组不良反应发生率及术后1周复发率比较差异未见统计学意义(P>0.05)。结论PsAF患者RFA中加伊布利特治疗,不会明显干扰患者的AA间期与QTc间期,但可以明显减轻术后心肌损伤并提高成功转复率,不会明显增加不良反应与复发。
ObjectiveTo investigate the effect of ibutilide in radiofrequency ablation(RFA)for persistent atrial fibrillation(PsAF).MethodsEighty patients with PsAF admitted to Jiaozuo People’s Hospital from June 2019 to June 2022 were selected,and they were divided into control group and observation group according to dichromatic sphere method,with 40 cases in each group.The control group was treated by RFA,and the observation group was treated with ibutilide base on the treatment in the control group.The successful cardioversion rate,cardioversion time,and peak time of corrected QT(QTc)interval were compared between the two groups.The levels of myocardial injury markers,AA interval,and QTc interval were compared between the two groups before and after surgery.The incidence of adverse reactions,recurrence rate within 1-week follow-up were compared between the two groups.ResultsThe successful cardioversion rate in the observation group(75.00%,30/40)was higher than that in the control group(52.50%,21/40),P<0.05.The cardioversion time and peak time of QTc interval in the observation group were shorter than those in the control group(P<0.05).There was no statistically significant difference in the levels of myocardial injury markers between the two groups before surgery(P>0.05);after surgery,the level of myocardial injury markers in the observation group were superior to those in the control group(all P<0.05).There was no significant difference in the AA interval and QTc interval between the two groups before and after surgery(all P>0.05).There was no statistically significant difference in the incidence of adverse reactions and recurrence rate within 1 week after surgery between the two groups(P>0.05).ConclusionsAdding ibutilide in RFA for PsAF will not significantly influence the AA interval and QTc interval of patients,however,it can significantly reduce postoperative myocardial injury and improve the successful cardioversion rate,without significantly increasing in adverse reactions and recurrence.
作者
尹遇冬
辛宾宾
马琳
赵晓旭
陈滢伊
逯保军
高爱玲
Yin Yudong;Xin Binbin;Ma Lin;Zhao Xiaoxu;Chen Yingyi;Lu Baojun;Gao Ailing(Department of Cardiovascular Medicine,Jiaozuo People’s Hospital,Jiaozuo 454000,China)
出处
《中国实用医刊》
2023年第13期100-103,共4页
Chinese Journal of Practical Medicine
关键词
射频消融
持续性心房颤动
伊布利特
心肌损伤标志物
复发
Radiofrequency ablation
Persistent atrial fibrillation
Ibutilide
Myocardial injury markers
Recurrence
