摘要
目的:研究含醇辅料药品在ICU内联合抗菌药物用药使用导致双硫仑不良反应的现状,为临床合理用药提供参考。方法:收集常州市第二人民医院在用的1674种西药说明书和181种中成药说明书汇总含醇辅料药物信息;另收集本院2021年1月—12月ICU出院病历资料共374份,统计含醇辅料药品在ICU患者中的应用情况。结果:1855份说明书中有37份说明书中明确标注了乙醇信息。在全年374份ICU出院病历中,使用含醇药物的病例共计103份(27.54%);其中涉及与抗菌药物联用的病例有54份(52.43%);因联合用药导致双硫仑不良反应的病例有9份(16.67%);9份病例中,药物重叠当天发生不良反应的有5例,药物重叠后第2天发生不良反应的有4例,有8例使用了头孢菌素类药物,有1例为喹诺酮类类药物。结论:含醇辅料药物在临床使用频繁,这些药品的说明书对含醇辅料信息标注不明确和不统一,不利于临床用药安全与联合用药指导。在ICU中,含醇辅料药品使用广泛,与可能发生双硫仑反应的抗菌药物联合使用情况也较多,存在一定的用药安全隐患。
Objective:To study the current situation of adverse reactions of disulfiram caused by the use of ethanol(medicinal excipients)combined with antibiotics in ICU,and to provide reference for clinical rational drug use.Methods:Collect 1674 kinds of western medicine instructions and 181 kinds of Chinese patent medicine instructions in Changzhou Second People’s Hospital to summarize the information of drugs containing ethanol(medicinal excipients);a total of 374 discharged medical records of ICU from January 2021 to December 2021 were collected,and the application of drugs containing ethanol(medicinal excipients)in ICU patients was counted.Results:Ethanol information was clearly marked in 37 of the 1855 instructions.Among the 374 ICU discharge medical records in the whole year,103 cases(27.54%)used ethanol(medicinal excipients);among them,54 cases(52.43%)were related to the combination of antibiotics;there were 9 cases(16.67%)of adverse drug reactions induced by combined use of disulfiram.Among the 9 cases,5 cases had adverse reactions on the day of drug overlap,4 cases had adverse reactions on the second day after drug overlap,8 cases used cephalosporins and 1 case used quinolones.Conclusion:Ethanol(medicinal excipients)are frequently used in clinical practice.The instructions of these drugs are not clear and uniform in labeling the information of ethanol(medicinal excipients),which is not conducive to clinical medication safety and combined medication guidance.In ICU,ethanol(medicinal excipients)are widely used,and there are many combined use of antibacterial drugs that may cause disulfiram reaction,which has certain drug safety risks.
作者
舒静雯
钱晓丹
蒋雨辰
SHU Jingwen;QIAN Xiaodan;Jiang Yuchen(Department of Pharmacy,Kangda College,Nanjing Medical University,Lianyungang 222006,Jiangsu,China;Department of Pharmacy,Nanjing Medical University Affiliated Second People’s Hospital of Changzhou,Changzhou 213100,Jiangsu,China;Department of Purchasing,Nanjing Medical University Affiliated Second People’s Hospital of Changzhou,Changzhou 213100,Jiangsu,China)
出处
《中国药物滥用防治杂志》
CAS
2023年第9期1533-1536,1550,共5页
Chinese Journal of Drug Abuse Prevention and Treatment
基金
常州市第十七批科技计划-应用基础研究指导性项目(编号:CJ20209010)。
关键词
含醇辅料
抗菌药物
双硫仑反应
合理用药
Ethanol(medicinal excipients)
Antibiotics
Disulfiram-like reaction
Rational use of drugs
