摘要
胶质母细胞瘤(GBM)是临床上常见且预后极差的胶质瘤类型,具有复杂的耐药机制,死亡率高,生存期短,侵袭性和复发是目前治疗的主要障碍。铁死亡是一种铁依赖性的大量脂质过氧化相关的调节性细胞死亡,与各种类型肿瘤的发展和治疗反应相关。癌细胞依靠其强大的抗氧化能力来避免铁死亡,因此,探索铁死亡可能是预防肿瘤增殖和侵袭的有效策略。文章主要对铁死亡在GBM中的作用机制,以及铁死亡作为潜在治疗靶点的研究进展进行综述。
Glioblastoma(GBM)is a clinically common type of glioma with a very poor prognosis and complex drug resistance mechanisms,high mortality,short survival time;invasiveness and recurrence are the main obstacles to treatment.Ferroptosis is an iron-dependent regulated cell death associated with massive lipid peroxidation that is related with the development and treatment response of various types of tumors.Cancer cells rely on their strong antioxidant capacity to avoid ferroptosis,therefore,exploring ferroptosis may be an effective strategy to prevent tumor proliferation and invasion.This article mainly reviews the mechanism of ferroptosis in GBM,as well as the research status and progress of ferroptosis as a potential therapeutic target.
作者
李鹏飞
吉宏明
张世渊
胡昌辰
Li Pengfei;Ji Hongming;Zhang Shiyuan;Hu Changchen(The Fifth Clinical Medical College of Shanxi Medical University,Taiyuan 030012,China;Department of Neurosurgery,Shanxi Provincial People's Hospital,Taiyuan 030012,China)
出处
《肿瘤研究与临床》
CAS
2023年第8期634-637,共4页
Cancer Research and Clinic
基金
国家自然科学基金(30901774)
山西省自然科学基金(2014011038-2)
山西省科学技术发展计划(20140313011-5)
山西省重点研发计划(国际科技合作项目)(201803D421055)
山西省留学人员科技活动项目(2018014)
山西省级专项配套经费科研项目(sj20019003)
山西省基础研究计划(20210302123352)
山西省卫生健康委科研课题(2022052)
山西省回国留学人员科研资助项目(2022-205)
山西省"四个一批"科技兴医创新项目(2022XM21)。