摘要
肺癌是全球死亡率最高的癌症, 严重威胁我国人民群众的生命健康。基于我国对肺癌精准诊疗的需求和研究现状, 针对早期肺癌的精准诊断、治疗后复发监测、靶向与免疫治疗耐药等问题, 需要提出针对患者的个体化解决方案并提供敏感性药物, 这需要为临床提供能够针对患者肿瘤组织病理和分子分型特点的研究模型。基于微流控技术的器官芯片模型将类器官培养技术与微流控技术相结合, 可以在3D培养的同时, 以组织工程技术和微制造技术来模拟人体器官的基本结构, 探究更为细致的生理病理反应;还能通过微流体控制和生物传感技术来进行更为快速高效的个性化药敏测试。该模型的出现极大地推动了肺癌领域的研究进展, 本文将对近几年基于微流控技术的肺芯片模型在肺癌研究中的应用进行综述, 并展望该技术在未来的发展。
Lung cancer is the cancer with the highest mortality rate in the world,which is a serious threat to the lives and health of our people.Based on the demand and research status of accurate diagnosis and treatment of lung cancer in China,aiming at the problems of accurate diagnosis,post-treatment recurrence monitoring,targeting and immunotherapy drug resistance of early lung cancer,it is necessary to propose individualized solutions for patients and provide sensitive drugs,which needs to provide clinical research models that can be based on the characteristics of tumor histopathology and molecular typing.The organ chip model based on microfluidic technology combines quasi-organ culture technology with microfluidic technology,which can simulate the basic structure of human organs with tissue engineering technology and micromanufacturing technology at the same time of 3D culture.To explore more detailed physiological and pathological responses,and more rapid and efficient personalized drug sensitivity testing can be carried out through microfluidic control and biosensor technology.The emergence of this model has greatly promoted the research progress in the field of lung cancer.This paper will review the application of lung chip model based on microfluidic technology in lung cancer research in recent years,and look forward to the development of this technology in the future.
作者
卢潇
邹正浩澜
林慧庆
Lu Xiao;Zou Zhenghaolan;Lin Huiqing(First Clinical College of Wuhan University,Wuhan 430060,China;Department of Thoracic Surgery,Renmin Hospital of Wuhan University,Wuhan 430060,China)
出处
《中华实验外科杂志》
CAS
北大核心
2023年第8期1649-1653,共5页
Chinese Journal of Experimental Surgery
基金
国家自然科学基金面上项目(82170106)
中国器官移植发展基金会(2020HX0011)。
关键词
微流控芯片
肺芯片
肺癌
Microfluidic chip
Lung-on-a-chip
Lung cancer
