摘要
目的:观察清热解毒汤联合火针治疗湿热蕴结型痤疮的临床效果,并分析对患者皮肤屏障功能的影响。方法:选取118例痤疮患者,按随机数字表法分为观察组和对照组各59例。对照组给予常规西药治疗,观察组在对照组基础上加用清热解毒汤及火针治疗,疗程4周。比较2组治疗前后主症评分、皮损积分、皮肤病理学特征和皮肤屏障功能变化,评估2组临床疗效,随访6个月,记录第3个月、第6个月复发率。结果:治疗后,2组主症评分及皮损评分较治疗前降低(P<0.05),且观察组主症评分及皮损评分低于对照组(P<0.05)。治疗后,2组红色区、紫质、棕色斑评分较治疗前降低(P<0.05);且观察组红色区、紫质、棕色斑评分低于对照组(P<0.05)。治疗后,2组经皮水分丢失量、皮肤黏脱蛋白质含量较治疗前降低,角质层含水量较治疗前增多(P<0.05);且观察组经皮水分丢失量、皮肤黏脱蛋白质含量低于对照组,角质层含水量高于对照组(P<0.05)。观察组总有效率为96.61%,高于对照组86.44%(P<0.05)。观察组第3个月、第6个月复发率均低于对照组(P<0.05)。结论:清热解毒汤联合火针治疗湿热蕴结型痤疮能减轻临床症状,改善皮肤病理学特征,提高皮肤屏障功能和临床疗效,减少复发。
Objective:To observe the clinical effect of Qingre Jiedu Decoction combined with fire needling for acne of damp-heat accumulation type,and to analyze its effect on skin barrier function.Methods:A total of 118 cases of patients with acne were selected and divided into the observation group and the control group according to the random number table method,with 59 cases in each group.The control group was treated with routine western medicine,and the observation group was additionally treated with Qingre Jiedu Decoction and fire needling based on the treatment of the control group.Both groups were treated for four weeks.The changes in main symptom scores,skin lesion scores,dermatopathological features,and skin barrier function in the two groups were compared before and after treatment,and the clinical effects in the two groups were evaluated.Both groups were followed up for six months,and the recurrence rates were recorded at the third and sixth months.Results:After treatment,the main symptom scores and skin lesion scores in the two groups were decreased when compared with those before treatment(P<0.05),and the main symptom score and skin lesion score in the observation group were lower than those in the control group(P<0.05).After treatment,the scores of red area,porphyrin,and brown spots of skin in the two groups were decreased when compared with those beforetreatment (P<0.05);the scores of red area,porphyrin,and brown spots of skin in the observation groupwere lower than those in the control group (P<0.05). After treatment, the percutaneous water loss andskin mucin contents were decreased when compared with those before treatment, and the stratumcorneum hydration in the two groups was increased when compared with that before treatment (P<0.05);the percutaneous water loss and skin mucin content in the observation group were lower than those in thecontrol group, and the stratum corneum hydration in the observation group was higher than that in thecontrol group (P<0.05). The total effective rate was 96.61% in the ob
作者
丁蓉
刘路星
DING Rong;LIU Luxing(Department of Dermatology,Third Hospital of Shaoxing,Shaoxing Zhejiang 312000,China)
出处
《新中医》
CAS
2023年第15期127-131,共5页
New Chinese Medicine
关键词
痤疮
火针
清热解毒汤
湿热蕴结型
皮损评分
皮肤屏障功能
复发率
Acne
Fire needling
Qingre Jiedu Decoction
Damp-heat accumulation type
Skin lesion scores
Skin barrier function
Recurrence rate
