摘要
目的:分析从五经辨证采用小儿推拿防治儿童矮身材的临床疗效及作用机理。方法:120例身材偏矮儿童根据随机数字表法将其分为2组,每组60例,对照组给予健康教育、强化营养支持与照护,不进行医疗干预,试验组在对照组基础上通过五经辨证给予推拿治疗,6个月为1个疗程,两个疗程后评价治疗效果。比较两组临床疗效、身高(height,Ht)、身高增长值(height increment,HGV)、生长速率(height velocity,HV)、胰岛素样生长因子-1(insulin-like growth factor-1,IGF-1)、25羟维生素D[25 hydroxyvitamin D,25-(OH)D]、类胰岛素生长因子结合蛋白3(insulin-like growth factor-binding protein3,IGFBP3)、骨代谢指标。结果:(1)试验组临床有效率为95.00%(57/60),对照组为75.00%(45/60),两组比较,差异有统计学意义(P<0.05)。(2)治疗6个月、12个月后,两组Ht、HGV、HV均高于本组治疗前,试验组Ht为(119.82±5.13)cm、(131.51±9.62)cm,HGV为(7.82±1.62)cm、(19.82±4.51)cm,HV为(3.98±0.52)、(5.38±1.04),均高于同期对照组,差异均有统计学意义(P<0.05)。(3)治疗6个月、12个月后,两组血清IGF-1、25-(OH)D、IGFBP3均高于本组治疗前,试验组血清IGF-1为(110.52±6.92)μg·L^(-1)、(140.62±8.14)μg·L^(-1),25-(OH)D为(23.88±2.62)μg·L^(-1)、(25.85±3.14)μg·L^(-1),IGFBP3为(3.38±0.52)μg·L^(-1)、(5.62±1.13)μg·L^(-1),均高于同期对照组,差异有统计学意义(P<0.05)。(4)治疗6个月、12个月后,两组血清I型前胶原氨基端前肽(procollagen type I N-terminal peopeptide,PINP)、I型胶原交联羧基末端肽(carboxytenninal telopeptide of typeⅠcollagen,ICTP)均高于本组治疗前,试验组血清PINP为(584.62±35.05)μg·L^(-1)、(645.82±61.55)μg·L^(-1),ICTP为(18.05±2.46)μg·L^(-1)、(22.92±3.75)μg·L^(-1),均高于同期对照组,差异有统计学意义(P<0.05)。结论:基于五经辨证采用推拿治疗儿童矮身材临床疗效显著,可有效促进身材偏矮儿童生长发育,提高血清IGF-1、25-(OH)D
Objective:To analyze the clinical effect and mechanism of preventing and treating children's short stature by using infantile massage based on syndrome differentiation of five meridians.Methods:120 children with short stature were randomly divided into two groups,with 60 cases in each group.The control group was given health education,strengthened nutritional support and care,and no medical intervention.The experimental group was given massage based on five meridians syndrome differentiation on basis of the control group,with 6 months as a course of treatment.The therapeutic effect was evaluated after two courses of treatment.The clinical efficacy,height(Ht),height increment(HGV),height velocity(HV),insulin-like growth factor-1,(IGF-1),25 hydroxyvitamin D[25-(OH)D],insulin-like growth factor-binding protein 3(IGFBP3),bone metabolism index.Results:(1)The clinical effective rate of the experimental group was 95.00%(57/60),while that of the control group was 75.00%(45/60).The difference was statistically significant(P<0.05).(2)After 6 months and 12 months of treatment,the Ht,HGV and HV in the two groups were higher than those before treatment.The Ht in the experimental group was(119.82±5.13)cm,(131.51±9.62)cm,and the HGV was(7.82±1.62)and(19.82±4.51).The difference was statistically significant(P<0.05).(3)After 6 months and 12 months of treatment,the levels of serum IGF-1,25-(OH)D and IGF-BP 3 in both groups were higher than those before treatment.In the experimental group,the serum IGF-1 was(110.52±6.92)μg·L^(-1),(140.62±8.14)μg·L^(-1),and the 25-(OH)D was(23.88±2.62)μg·L^(-1) and(25.85).The difference was statistically significant(P<0.05).(4)After 6 months and 12 months of treatment,the serum procollagen type I N-terminal peopeptide(PINP)and collagen type I crosslinked carboxyl terminal peptide(ICTP)in both groups were higher than those before treatment.In the experimental group,the serum PINP was(584.62±35.05)μg·L^(-1),(645.82±61.55)μg·L^(-1),and the ICTP was(18.05±2.46)μg·L^(-1) and(22.92±
作者
李凌云
吴钱红
李俊达
刘世东
赵翎惠
LI Lingyun;WU Qianhong;LI Junda;LIU Shidong;ZHAO Linghui(Nanxishan Hospital of Guangxi Zhuang Autonomous Region,Guilin Guangxi China 541002)
出处
《中医学报》
CAS
2023年第10期2240-2246,共7页
Acta Chinese Medicine
基金
广西壮族自治区中医药管理局科研项目(CZZC2019120)。
关键词
儿童矮身材
五经辨证
小儿推拿
胰岛素样生长因子1
25羟维生素D
类胰岛素生长因子结合蛋白3
short stature of children
syndrome differentiation of five meridians
children massage
insulin-like growth factor 1
25 hydroxyvitamin D
insulin-like growth factor binding protein 3
