摘要
目的探讨外用重组人表皮生长因子凝胶联合曲安奈德软膏治疗口腔溃疡患者的效果及临床应用价值。方法104例口腔溃疡患者,采用随机抽样法分成常规组和研究组,每组52例。常规组外用重组人表皮生长因子凝胶单独治疗,研究组外用重组人表皮生长因子凝胶联合曲安奈德软膏治疗。比较两组治疗效果、不良反应发生情况、愈合情况、不良情绪、炎性因子水平、疼痛程度、复发率。结果研究组治疗总有效率96.15%高于常规组的80.77%,差异具有统计学意义(P<0.05)。研究组溃疡个数(0.38±0.16)个少于常规组的(1.39±0.51)个,溃疡面积(0.15±0.08)mm^(2)小于常规组的(1.68±0.43)mm^(2),疼痛缓解时间(2.64±0.44)d、溃疡愈合时间(4.43±1.18)d、症状消退时间(6.26±2.05)d、进食改善时间(2.31±0.87)d短于常规组的(4.85±0.73)、(7.78±2.18)、(8.32±2.75)、(5.23±1.13)d,差异具有统计学意义(P<0.05)。治疗后,研究组白细胞介素-6、白细胞介素-2、肿瘤坏死因子-α水平分别为(1.05±0.01)、(46.57±4.71)、(10.25±2.45)pg/ml,均低于常规组的(1.88±0.43)、(58.34±3.79)、(13.45±3.12)pg/ml,差异具有统计学意义(P<0.05)。治疗后,研究组焦虑、抑郁、疼痛评分分别为(41.34±2.51)、(42.04±1.36)、(1.01±0.30)分,低于常规组的(52.86±2.58)、(52.73±1.38)、(2.67±0.79)分,差异具有统计学意义(P<0.05)。研究组复发率低于常规组,差异具有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论口腔溃疡患者应用外用重组人表皮生长因子凝胶联合曲安奈德软膏进行治疗,可以降低其疼痛程度,促进愈合,降低复发率,改善患者炎性因子水平,治疗效果显著,临床应用价值较高。
Objective To discuss the effect and clinical value of recombinant human epidermal growth factor gel combined with triamcinolone acetonide ointment in the treatment of oral ulcer.Methods A total of 104 patients with oral ulcer were divided into conventional group and study group by random sampling method,with 52 cases in each group.The conventional group was treated with topical recombinant human epidermal growth factor gel alone,and the study group was treated with topical recombinant human epidermal growth factor gel and triamcinolone olone ointment.The therapeutic effect,occurrence of adverse reactions,healing,adverse emotions,inflammatory factor level,pain level and recurrence rate were compared between the two groups.Results The total effective rate of the study group was 96.15%,which was higher than that of 80.77%of the conventional group,and the difference was statistically significant(P<0.05).The number of ulcers of(0.38±0.16)ulcers in the study group was less than that of(1.39±0.51)ulcers in the conventional group;the ulcer area of(0.15±0.08)mm^(2)in the study group was smaller than that of(1.68±0.43)mm^(2)in the conventional group;in the study group,the time for pain relief was(2.64±0.44)d,the time for ulcer healing was(4.43±1.18)d,the time for symptom resolution was(6.26±2.05)d,and the time for food intake improvement was(2.31±0.87)d,which were shorter than those of(4.85±0.73),(7.78±2.18),(8.32±2.75),and(5.23±1.13)d in the conventional group;the differences were statistically significant(P<0.05).After treatment,the levels of interleukin-6,interleukin-2 and tumor necrosis factor-αwere(1.05±0.01),(46.57±4.71)and(10.25±2.45)pg/ml,which were lower than those of(1.88±0.43),(58.34±3.79)and(13.45±3.12)pg/ml in the conventional group,and the differences were statistically significant(P<0.05).After treatment,the scores of anxiety,depression and pain in the study group were(41.34±2.51),(42.04±1.36)and(1.01±0.30)points,which were lower than those of(52.86±2.58),(52.73±1.38)and(2.67±0.79)po
作者
钟翠翠
张义喜
苗玉珠
谢义璞
ZHONG Cui-cui;ZHANG Yi-xi;MIAO Yu-zhu(Stomatology Department,Yanggu County People's Hospital,Liaocheng 252300,China)
出处
《中国现代药物应用》
2023年第17期16-20,共5页
Chinese Journal of Modern Drug Application
关键词
外用重组人表皮生长因子凝胶
曲安奈德软膏
口腔溃疡
Recombinant human epidermal growth factor gel
Triamcinolone acetonide ointment
Oral ulcer
