摘要
目的:通过Meta分析总结我国不同地区无偿献血者人群中HPV-B19DNA阳性率情况,推测无偿献血者人群中HPV-B19感染现状,为制定HPV-B19血液筛查方案提供依据。方法:根据关键词检索中国知网、万方医学、PubMed等数据库,筛选符合纳入标准的文献,提取文献中HPV-B19DNA阳性率数据后运用R4.1.3软件进行Meta分析。结果:获得符合标准的15篇文献共计调查34878份无偿献血者标本,Meta分析得出中国无偿献血者人群中HPV-B19DNA阳性率合并值为0.7%[95%CI(0.3%~1.2%)],且各地区间阳性率存在显著差异。结论:HPV-B19在中国无偿献血者中感染率较低,不同地区无偿献血者人群HPV-B19感染率存在较大的差异。各城市和地区应合理评估本地区无偿献血人群HPV-B19感染水平,制定适宜的筛查方案。
Objective:To summariz the positive rate of HPV-B19 DNA and speculate the current situation of HPV-B19 infection among voluntary blood donors in different regions of China by meta-analysis,providing a basis for the strategy of blood screening program for HPV-B19.Methods:Search key words in databases such as CNKI,Wanfang Medical,PubMed,etc and select articles meeting the inclusion criteria.Extract the data of DNA positive rate in literature and then use R4.1.3 software for meta analysis.Results:A total of 34878 voluntary blood donor samples were investigated and a meta-analysis of HPV-B19 DNA positive rate was assessed in 15 eligible articles.The pooled estimates positive rate of HPV-B19 DNA was estimated to be 0.7%[95%CI:(0.3%~1.2%)]and there was significant heterogeneity among samples in different regions.Conclusion:The overall prevalence of HPV-B19 among voluntary blood donors is low in China.HPV-B19 infections in voluntary blood donors varied significantly between regions.Domestic cities and regions should reasonably assess HPV-B19 virus infection status to formulate appropriate HPV-B19 virus screening programs for voluntary blood donors.
作者
谢月娜
李凤园
刘淼
姚娜
潘彤
XIE Yuena;LI Fengyuan;LIU Miao(Department of Laboratory Medicine,Tianjin Blood Center,Tianjin 300110)
出处
《医学检验与临床》
2023年第8期41-45,共5页
Medical Laboratory Science and Clinics
