摘要
目的:探讨血凝酶联合生长抑素治疗急性上消化道出血(AUGIB)的效果。方法:采用随机数字表法将92例AUGIB患者分为对照组和观察组。对照组行常规治疗和生长抑素治疗,观察组在对照组基础上加用血凝酶治疗。结果:观察组总有效率高于对照组,肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、皮质醇(COR)、抗利尿激素(ADH)、去甲肾上腺素(NE)的水平均低于对照组,凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)均短于对照组,纤维蛋白原(FIB)水平高于对照组,止血时间、住院时间、腹痛时间、呕血时间均短于对照组,输血量和黑便次数均少于对照组,以上差异均有统计学意义(P<0.05)。两组不良反应比较,差异无统计学意义(P>0.05)。结论:应用血凝酶联合生长抑素治疗AUGIB患者效果显著,安全性好。
Objective:To investigate the efficacy of hemagglutinin combined with somatostatin in the treatment of acute upper gastrointestinal bleeding(AUGIB).Methods:92 patients with AUGIB were divided into the control group and observation group according to the random number table method.The control group received routine treatment and somatostatin treatment,while the observation group received additional treatment with hemagglutinin on top of the control group.Results:The total effective rate of the observation group was higher than that of the control group.The levels of Tumor necrosis factor-α(TNF-α),hypersensitive C-reactive protein(hs-CRP),cortisol(COR),antidiuretic hormone(ADH),and norepinephrine(NE)were lower than those of the control group.Prothrombin time(PT)and activated partial thromboplastin time(APTT)were shorter than those in the control group,and fibrinogen(FIB)levels were higher than those in the control group.The time to hemostasis,hospitalization time,abdominal pain time,and vomiting time were shorter than those in the control group.The volume of blood transfusion and the number of black stools were less than those in the control group.All the above differences were statistically significant(P<0.05).There was no statistically significant difference in adverse reactions between the two groups(P>0.05).Conclusion:The treatment of AUGIB patients using hemagglutinin combined with somatostatin has a significant effect and good safety.
作者
胡霞
邹小林
HU Xia;ZOU Xiaoin(Xinyu Yinhe Hospital,Xinyu 338000,China)
出处
《华夏医学》
CAS
2023年第4期88-92,共5页
Acta Medicinae Sinica
基金
新余市社会发展指导性科技计划项目(20213090958)。
关键词
急性上消化道出血
血凝酶
生长抑素
炎症因子
应激反应
不良反应
acute upper gastrointestinal bleeding
hemagglutinin
somatostatin
inflammatory factor
stress response
adverse reaction
