摘要
目的探讨消化内镜治疗上消化道出血(UGB)的疗效及对应激反应、炎症因子及并发症发生率的影响。方法选取2019年5月至2021年5月枣庄市峄城区人民医院收治的100例UGB患者作为研究对象,按照随机数字表法分为观察组与对照组,每组50例。对照组行常规药物治疗,观察组行消化内镜治疗,比较两组应激反应指标[抗利尿激素(ADH)、皮质醇(Cor)、生长激素(GH)]、血清炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]水平、并发症发生率及临床疗效。结果治疗后,两组ADH、Cor、GH水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组TNF-α、IL-6水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组并发症发生率(2.00%)低于对照组(16.00%),差异有统计学意义(P<0.05);观察组治疗总有效率(94.00%)高于对照组(74.00%),差异有统计学意义(P<0.05)。结论消化内镜治疗UGB疗效显著,能减轻机体应激、炎症反应,降低并发症发生率,值得临床推广应用。
Objective To investigate the clinical efficacy of digestive endoscopy in the treatment of upper gastrointestinal bleeding(UGB)and its influence on stress response,inflammatory factors and the incidence of complications.Methods 100 patients with UGB treated in People's Hospital of Yicheng District,Zaozhuang City from May 2019 to May 2021 were selected as the research subjects,and they were divided into the observation group and the control group according to the random number table method,with 50 cases in each group.The control group received routine medication treatment,while the observation group received digestive endoscopy treatment,the stress response indicators(antidiuretic hormone[ADH],cortisol[Cor],growth hormone[GH]),serum inflammatory factor(tumor necrosis factor-α[TNF-α],interleukin-6[IL-6])levels,incidence of complications,and clinical efficacy were compared between the two groups.Results After treatment,the levels of ADH,Cor and GH of the two groups were lower than those before treatment,and the observation group were lower than the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of TNF-α,IL 6 of the two groups were lower than those before treatment,and the observation group were lower than the control group,the differences were statistically significant(P<0.05).The incidence of complications in the observation group(2.00%)was lower than that in the control group(16.00%),the difference was statistically significant(P<0.05).The total effective rate of treatment in the observation group(94.00%)was higher than that in the control group(74.00%),the difference was statistically significant(P<0.05).Conclusion Digestive endoscopy is effective in the treatment of UGB,which can reduce stress and inflammatory of the body,and reduce the incidence of complications,and is worthy of clinical promotion and application.
作者
宋波
SONG Bo(Department of Gastroenterology,People's Hospital of Yicheng District,Zaozhuang City,Zaozhuang,Shandong,277300,China)
出处
《当代医学》
2023年第19期91-94,共4页
Contemporary Medicine
关键词
消化内镜
上消化道出血
临床疗效
并发症发生率
Digestive endoscopy
Upper gastrointestinal bleeding
Clinical efficacy
Incidence of complication
