摘要
目的:比较研究内镜止血联合不同剂量质子泵抑制剂治疗老年急性非静脉曲张性上消化道出血的临床效果,为以后临床治疗提供参考依据.方法:选取2009-01/2014-12 206例内镜止血治疗的老年急性非静脉曲张性上消化道出血患者为研究对象,治疗中依据不同剂量质子泵抑制剂含量分为观察组与对照组,均103例.对照组患者治疗中应用常规剂量质子泵抑制剂,观察组患者治疗中给予大剂量质子泵抑制剂.对比两组患者呕血、黑便持续时间、平均住院时间及输血量与再次出血的基本情况,观察其临床疗效.结果:(1)症状持续时间:观察组呕血、黑便持续时间、平均住院时间及输血量均少于对照组(1.12 d±0.38 d vs 3.47 d±0.53 d,3.22d±0.46 d vs 5.35 d±1.11 d,7.17 d±1.32 d vs 10.57 d±1.79 d,440.30 mL±86.65 mL vs764.50 mL±125.36 mL)(P<0.05);(2)止血情况:观察组止血时间、止血后再次出血、转开腹手术率低于对照组(1.62 h±0.69 h vs3.49 h±1.03 h,3.88%vs 13.59%,0.97%vs5.83%)(P<0.05).结论:临床中对于内镜治疗急性非静脉曲张性上消化道出血患者应用大剂量质子泵抑制剂可以更好的缩短患者的呕血、黑便持续时间,并且减少患者住院的时间.同时,对降低再出血也有明显的优势,值得临床中应用与推广.
AIM：To compare the clinical effects of endoscopic hemostat combined with different doses of proton pump inhibitor（PPI） in the treatment of elderly patients with acute non-varicoseupper gastrointestinal bleeding.METHODS：Two hundred and six elderly patients with acute non-varicose upper gastrointestinal bleeding treated from January 2009 to December 2014 were divided and equally into either a high-or a conventional-dose PPI group.Patients in the conventional-dose group were given a conventional dose of PPI,while the high-dose group was given a high dose.Both groups of patients received endoscopic hemostasis.The duration of vomiting and melena,average length of hospital stay,volume of blood transfusion,re-bleeding and clinical efficacy were compared for the two groups.RESULTS：The duration of vomiting and melena,average length of hospital stay and volume of blood transfusion were significantly lower in the high-dose group than in the conventional-dose group（1.12 d ± 0.38 d vs 3.47 d ± 0.53 d,3.22 d ± 0.46 d vs 5.35 d ± 1.11 d,7.17 d± 1.32 d vs 10.57 d ± 1.79 d,440.30 mL ± 86.65 mL vs 764.50 mL ± 125.36 mL,P〈0.05）.The time to hemostasis,rebleeding rate,and rate of conversion to open surgery were significantly lower in the high-dose group than in the conventional-dose group（1.62 h ± 0.69 h vs 3.49 h ± 1.03 h,3.88% vs13.59%,0.97% vs 5.83%,P〈0.05）.CONCLUSION：Endoscopic hemostat combined with high-dose PPI for acute non-varicose upper gastrointestinal bleeding is better in shortening the duration of vomiting and melena and reducing hospitalization time and rebleeding.
出处
《世界华人消化杂志》
CAS
2015年第18期2953-2956,共4页
World Chinese Journal of Digestology
关键词
内镜止血
急性非静脉曲张性上消化道出血
泮托拉唑
剂量
Endoscopic hemostat
Acute non-varicose upper gastrointestinal bleeding
Pantoprazole
Dose
