摘要
目的探讨脑脉利颗粒对急性脑梗死患者神经功能、血液流变学及血清学指标水平的影响。方法依据随机数表法将80例急性脑梗死患者分为对照组与观察组,各40例。2组均给予常规治疗,对照组在常规治疗基础上给予阿加曲班注射液进行治疗,观察组在对照组基础上给予脑脉利颗粒进行治疗,2组均持续治疗1周。比较2组治疗1周后的疗效,治疗前和治疗1周后神经功能、生活质量、凝血功能、血液流变学、血清学指标及治疗期间的安全性。结果与对照组比较,观察组治疗1周后总有效率(95.00%,38/40)高于对照组(75.00%,30/40)(P<0.05)。治疗1周后,2组NIHSS评分、m Rs评分、血清FIB、IL-8、IL-6、hs-CRP、TNF-α水平及全血低、高切黏度、血浆黏度、红细胞聚集指数、红细胞压积较治疗前降低,观察组低于对照组(P<0.05);2组血清PT、APTT较治疗前延长,观察组长于对照组(P<0.05);2组BI、ADL评分较治疗前升高,观察组高于对照组(P<0.05)。观察组治疗期间的不良反应发生率低于对照组(P<0.05)。结论脑脉利颗粒可有效调节急性脑梗死患者血液流变学、血清学指标水平,减轻机体炎症,改善血流动力学、凝血功能及神经功能,提高生活质量,疗效显著,安全性较高。
Objective To explore the effects of Naomaili granules on the neurological function,the index levels of hemorheology and serology in patients with acute cerebral infarction.Methods From October 2021 to September 2022,80 patients with acute cerebral infarction admitted in the Department of Neurology of Baoding First Central Hospital were divided into a control group(40 cases)and a test group(40 cases)according to the principle of random number table.Both groups were given a conventional treatment,and the control group was additionally given agatroban injections,while the test group was given Naomaili granules on the basis of the control group.Both groups were treated for one week.The curative effect after one week of treatment,the neurological function,quality of life,coagulation function,index levels of hemorheology and serology before and after one week of treatment and the safety during the treatment were compared between the two groups.Results Compared with the control group,the total effective rate of the test group was higher after one week of treatment(95.00%vs 75.00%,P<0.05).After one week of treatment,the scores of NIHSS,mRs,the levels of serum FIB,IL-8,IL-6,hs-CRP and TNF-α,the whole blood low and high shear viscosity and plasma viscosity,the erythrocyte aggregation indexes,hematocrit were decreased compared with those before treatment,and the test group was lower than the control group(P<0.05);the levels of serum PT and APTT of the two groups were longer than before treatment,and the test group was longer than the control group(P<0.05);the scores of BI and ADL in the two groups were higher than those before treatment,and those in the test group were higher than those in the control group(P<0.05).Compared with that in the control group,the incidence of adverse reactions in the test group was lower(5.00%vs 20.00%,P<0.05).Conclusion Naomaili granules can effectively regulate the levels of hemorheology and serology indicators in patients with acute cerebral infarction,reduce inflammation of the body,improve
作者
钱倩
张静
边伟林
邢晓明
张欣
高娟
QIAN Qian;ZHANG Jing;BIAN Weilin;XING Xiaoming;ZHANG Xin;GAO Juan(Department of Neurology,the First Central Hospital of Baoding,Baoding 071000,China;Department of Radiology,Baoding People's Hospital,Baoding 071000,China)
出处
《吉林中医药》
2023年第9期1042-1046,共5页
Jilin Journal of Chinese Medicine
基金
河北省卫生健康委科研基金项目(20220288)。
