摘要
目的:观察脑脉利颗粒联合阿替普酶静脉溶栓治疗急性脑梗死患者的效果。方法:选取2020年12月至2022年12月该院收治的80例急性脑梗死患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各40例。对照组采用阿替普酶静脉溶栓治疗,观察组在对照组基础上联合脑脉利颗粒治疗,比较两组临床疗效,治疗前后血流动力学指标(血细胞比容、血浆黏度、全血低切黏度)水平、神经功能指标[神经元特异性烯醇化酶(NSE)、神经生长因子(NGF)、脑源性神经营养因子(BDNF)]水平和氧化应激指标[谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)、丙二醛(MDA)]水平,以及不良反应发生率。结果:观察组治疗总有效率为95.00%(38/40),高于对照组的72.50%(29/40),差异有统计学意义(P<0.05);治疗后,两组血细胞比容、血浆黏度、全血低切黏度均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组血清NSE、NGF水平均低于治疗前,且观察组低于对照组,两组血清BDNF水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组GSH-Px、SOD水平均高于治疗前,且观察组高于对照组,两组MDA水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组治疗期间均未见明显不良反应。结论:脑脉利颗粒联合阿替普酶静脉溶栓治疗急性脑梗死患者可提高治疗总有效率,改善神经功能指标和氧化应激指标水平,降低血流动力学指标水平,效果优于单纯阿替普酶静脉溶栓治疗。
Objective:To observe effects of Naomaili granules combined with Alteplase intravenous thrombolysis in treatment of patients with acute cerebral infarction.Methods:A prospective study was conducted on 80 patients with acute cerebral infarction admitted to this hospital from December 2020 to December 2022.They were divided into control group and observation group according to the random number table method,40 cases in each group.The control group was treated with Alteplase intravenous thrombolysis,while the observation group was treated with Naomaili granules on the basis of that of the control group.The clinical efficacy,the levels of hemodynamic indexes(hematocrit,plasma viscosity,whole blood low shear viscosity),the levels of neurological function indexes[neuron-specific enolase(NSE),nerve growth factor(NGF),brainderived neurotrophic factor(BDNF)]and oxidative stress indexes[glutathione peroxidase(GSH-Px),superoxide dismutase(SOD),malondialdehyde(MDA)],and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of treatment in the observation group was 95.00%(38/40),which was higher than 72.50%(29/40)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of hematocrit,plasma viscosity and whole blood low shear viscosity of the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of serum NSE and NGF in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;the serum BDNF levels of the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;the levels of GSH-Px and SOD in the two groups were higher than those before the treatment,and those in the observation group were higher than those
作者
贺维理
HE Weili(Emergency Department of Lengshuitan Hospital of Yongzhou Central Hospital,Yongzhou 425000 Hunan,China)
出处
《中国民康医学》
2023年第12期78-81,共4页
Medical Journal of Chinese People’s Health
关键词
脑脉利颗粒
阿替普酶
静脉溶栓
急性脑梗死
血流动力学
氧化应激
神经功能
Naomaili granules
Alteplase
Intravenous thrombolysis
Acute cerebral infarction
Hemodynamics
Oxidative stress
Neurological function
