摘要
目的:观察子宫动脉多普勒参数联合血清血管生成素-2(Ang-2)、环氧化酶-2(COX-2)诊断子宫内膜异位症(EMS)价值。方法:选取医院2019年2月~2021年12月收治的86例EMS患者为EMS组,同期非EMS妇科良性疾病患者86例为对照组。均行彩色多普勒超声检查,测定子宫动脉多普勒参数[舒张末期流速(EDV)、收缩期峰值流速(PSV)、搏动指数(PI)、阻力指数(RI)],检测血清Ang-2、COX-2水平,绘制受试者工作特征(ROC)曲线分析上述指标诊断EMS价值,观察不同临床分期EMS患者各指标水平及与临床分期关系。结果:EMS组EDV、PSV低于对照组,PI、RI及血清Ang-2、COX-2水平高于对照组(P<0.05);ROC曲线显示,多普勒参数、血清Ang-2、COX-2联合诊断EMS的曲线下面积(AUC)最大为0.983,其诊断灵敏度96.5%、特异度96.5%;EMS患者随着临床分期增高EDV、PSV逐渐降低,血清Ang-2、COX-2水平逐渐增高(P<0.05);Spearman相关分析显示,EDV、PSV与EMS患者临床分期呈负相关,血清Ang-2、COX-2水平与患者临床分期呈正相关(均P<0.05)。结论:子宫动脉多普勒参数联合血清Ang-2、COX-2与患者病情程度有关,联合检测EMS诊断效能较高。
Objective:To observe the value of the uterine artery Doppler parameters combined with the levels of serum angiopoietin-2(Ang-2)and cyclooxygenase-2(COX-2)of women for diagnosing their endometriosis(EMS).Methods:86women with EMS were selected in study group,and 86women with gynecological benign diseases and without EMS were selected in control group from February 2019to December 2021.Color Doppler ultrasonography was performed for the women in the two groups to measure their uterine artery Doppler parameters,such as end-diastolic velocity(EDV),peak systolic velocity(PSV),pulsatility index(PI),and resistance index(RI).The serum Ang-2and COX-2levels of the women in the two groups were detected.Receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic values of the uterine artery Doppler parameters,and the levels of the serum Ang-2and COX-2of the women for their EMS.The correlation between the uterine artery Doppler parameters and the levels of the serum Ang-2and COX-2of the women with different stage of EMS and their clinical EMS stages was observed.Results:The values of EDV and PSV of the women in the study group were significantly lower than those of the women in the control group.The values of PI and RI and the serum Ang-2and COX-2levels of the women in the study group were significantly higher than those of the women in the control group(P<0.05).ROC curve showed that the maximum area under the curve(AUC)of the combination of the values of Doppler parameters and the levels of serum Ang-2and COX-2 of the women for diagnosing their EMS was 0.983,and the sensitivity and the specificity of which were 96.5%was 96.5%.The values of EDV and PSV of the women with EMS had decreased gradually with their increased clinical stage of EMS,and the serum Ang-2and COX-2levels of the women with EMS had increased gradually with their increased clinical stage of EMS(P<0.05).Spearman correlation analysis showed that the values of EDV and PSV of the women with EMS were negatively correlated with their clinical sta
作者
成立
李阳
陈宁
江慧
CHENG Li;LI Yang;CHEN Ning;JIANG Hui(Mengcheng First People's Hospital,Bozhou,Anhui Province,233500;The First Affiliated Hospital of Bengbu Medical College,Bengbu,Anhui Province)
出处
《中国计划生育学杂志》
2023年第9期2152-2156,共5页
Chinese Journal of Family Planning
